Young onset Parkinson’s disease patient who has GBA1 pathogenic variant exhibiting progressive supranuclear palsy phenotype
Objective: We experience the GBA1 gene related YOPD who showed the progressive supranuclear palsy (PSP) phenotype. Background: Glucocerebrosidase (GBA1) gene mutations are well-known genetic risk…Clinical and Kinematic Evaluation of a Tremor-Damping Glove in Essential Tremor
Objective: To evaluate the clinical and kinematic efficacy of a biomechanical glove-based tremor dampener in essential tremor (ET) patients. Background: ET is a common movement…Automated Image-guided Programming for DBS Matches Expert Clinician Programming
Objective: To compare Volumes of Tissue Activated (VTA) locations and motor outcomes in Parkinson’s Disease (PD) patients across three programming strategies: manual image-guided programming (mIGP),…Multilingual Smartphone Application for Objective Motor Assessment in Parkinson Disease: Cross-Sectional Clinical Validation Study
Objective: To assess the clinical validity of an Android-based application for remote, objective quantification of tremor and hand bradykinesia (2D) in Parkinson’s disease against reference-standard…Upper Limb Coordination During Walking is Associated with Clinical Severity in Parkinson’s Disease
Objective: To explore the clinical relevance of upper limb coordination in PD, measured by wearable sensors, and quantified using continuous relative phase (CRP). Background: Upper…Neuropsychiatric Symptoms in Parkinson’s Disease in Low- and Middle-Income Countries: A Systematic Review
Objective: To assess the prevalence and patterns of neuropsychiatric symptoms among patients with Parkinson’s disease in low- and middle-income countries (LMICs). Background: Neuropsychiatric manifestations such…Directional versus Omnidirectional GPi-DBS in Parkinson’s Disease
Objective: To compare short-term motor and non-motor outcomes following directional versus omnidirectional stimulation in Parkinson’s disease (PD) cases undergoing bilateral globus pallidus internus (GPi) DBS…Prosaposin differentially modulates lipid metabolism of striatal and non-striatal dopamine D1 receptor-expressing neurons and regulates L-DOPA-induced dyskinesia
Objective: Chronic treatment of L-DOPA causes dyskinesia (LID) in PD patients. We aim to understand LID from a lipid-metabolism perspective and identify novel therapeutic targets.…Prosodic speech variability is associated with speech-related stigma in Parkinson’s disease
Objective: To investigate whether objective acoustic speech parameters are associated with perceived speech-related stigma in Parkinson’s disease (PD). Background: Speech impairment is common in PD…When “Essential Tremor Plus” Is Not Enough: A Tremor-Dominant Presentation of Neuronal Intranuclear Inclusion Disease
Objective: To describe a tremor-dominant presentation of neuronal intranuclear inclusion disease (NIID) that initially resembled essential tremor plus (ET-plus), highlighting the need for diagnostic reconsideration…
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