18F-FD4 PET Reveals α-Synuclein Deposition and Clinical Correlations in Multiple System Atrophy
Objective: This study aimed to determine the potential of 18F-FD4 PET to serve as an in vivo pathology mapping tool for MSA, providing initial proof-of-concept for its use in…Real-world variability in dosing of continuous subcutaneous foslevodopa/foscarbidopa infusion in advanced Parkinson’s disease: evidence from a single-center cohort
Objective: To evaluate dosing patterns, demographic characteristics, and safety outcomes in patients with advanced Parkinson's Disease (PD) treated with continuous subcutaneous foslevodopa/foscarbidopa infusion in routine…Baseline Characteristics of Participants Enrolled in a Randomised Pilot Study of Enhanced Tai Chi for Parkinson’s disease
Objective: To describe the baseline characteristics of participants enrolled in a pilot randomised controlled study evaluating Enhanced Tai Chi for Parkinson’s disease (NCT07297368). Background: Exercise-based…Stimulation-Induced Laryngospasm During Awake Ventral Intermediate Nucleus Deep Brain Stimulation for Essential Tremor
Objective: To report a rare case of acute laryngospasm during intraoperative stimulation in VIM-DBS surgery. Background: Deep brain stimulation (DBS) of the ventral intermediate nucleus…Clinical Predictors of Cognitive Decline in Parkinson’s Disease: A Longitudinal Cohort Study
Objective: To identify clinical predictors associated with progression of cognitive impairment in patients with Parkinson’s disease. Background: Cognitive impairment is a common non-motor manifestation of…Clinical Outcomes Of Globus Pallidus Internus Deep Brain Stimulation In ADCY5-Related Dyskinesia: A Case Series From A Tertiary Movement Disorders Center
Objective: To describe the clinical outcomes of globus pallidus internus deep brain stimulation (DBS-GPi) in three patients with genetically confirmed ADCY5 mutation. Background: ADCY5 dyskinesia…Clinical Evaluation of TT-P34: Exploring Safety and CSF Exposure in Parkinson’s Disease Patients
Objective: Evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of TT-P34 in cerebrospinal fluid (CSF) following multiple subcutaneous (SC) doses in Parkinson’s disease patients…Age of Onset as a Predictor of NonMotor Symptom Severity in Parkinson’s Disease
Objective: To examine the influence of age of onset on the non-motor symptom (NMS) burden among individuals with Parkinson’s disease (PD) in Singapore. Background: Non-motor…Cerebral Small Vessel Disease Burden and Motor Phenotype Expression in Parkinsonian Syndromes: A Quantitative Neuroimaging Analysis
Objective: To characterize the relationship between composite cerebral small vessel disease (CSVD) burden and motor phenotype severity across a clinically heterogeneous cohort of patients with…Regional Basal Ganglia Hypoperfusion in Early Parkinson’s Disease: Evidence from CT Perfusion Imaging
Objective: To characterize region-specific cerebral perfusion alterations within the basal ganglia in patients with early-stage Parkinson's disease using quantitative CT perfusion imaging. Background: Emerging evidence…
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