Social Network Structure and Caregiving Experiences in South Asian Families Living with Dementia Associated with Parkinsonian Disorders
Objective: To characterize social network structure and caregiving among SA families with Parkinsonian dementia (PD) and compare them with White American (WA) caregiving networks. Background:…Multimodal Elastography-Assisted Quantitative Evaluation Tool for Diagnosing Rigidity in Parkinson’s Disease
Objective: To investigate the feasibility of multimodal elastography for quantifying rigidity in PD and to screen for diagnostically valuable muscle indicators to construct a non-invasive…Deep Learning-Enhanced Multimodal MRI for Real-World Differentiation of Parkinsonian Disorders
Objective: To develop and evaluate an integrated, deep learning (DL)-enhanced multimodal MRI classification model combining nigrosome-1 (N1), neuromelanin (NM), free-water DTI (FW-DTI) and morphometry (MORPHO)…Disassembly of α-Synuclein Aggregates by the All-D-peptide PRI-101: Preclinical Efficacy in Vitro and in Vivo.
Objective: To develop a disease-modifying therapy for Parkinson’s disease (PD) and related synucleinopathies by eliminating intracellular, toxic, and seeding-competent aggregate species of α-synuclein (α-syn). Background:…Diagnosis and therapeutic approaches for sialorrhea in patients with Parkinson’s disease.
Objective: To study the frequency of drooling complaints in Parkinson's disease (PD) patients during outpatient visits. Background: Sialorrhea (excessive drooling) is a non-motor symptom of…Diagnostic Accuracy of NPH by Radiographic Suspicion and Effect on Patient Outcomes
Objective: Our study examines the radiographic accuracy when suggesting normal pressure hydrocephalus (NPH), correlation with imaging study indication, and frequency of lumbar puncture (LP) for…Early Manifestations of Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS) Include Dystonic Laryngeal Phenomena
Objective: To describe four patients in whom laryngeal dystonia manifesting as cough and spasmodic dysphonia preceded Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS)…GLP1R Expression and Parkinson’s Disease and Related Disorders in GLP-1RA–Treated Type 2 Diabetes
Objective: We tested whether interindividual differences in systemic GLP1R expression are associated with PDRD risk among adults with type 2 diabetes initiating GLP-1RAs. Background: Preclinical…Motor and Quality‑of‑Life Outcomes After MR‑Guided Focused Ultrasound Subthalamotomy for Parkinson’s Disease: A Meta‑analysis
Objective: To evaluate the efficacy and safety of MR guided focused ultrasound (MRgFUS) subthalamotomy for improving motor symptoms, medication burden, and quality of life inParkinson’s…Ante-Mortem Motor Speech Profiles in Postmortem Confirmed Atypical Parkinsonisms
Objective: Differences in motor speech profiles may aid in diagnosis of atypical parkinsonisms. This is a retrospective study that characterizes ante-mortem motor speech profiles in postmortem…
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