Genome-wide Discovery of GBA1 Modifiers in Parkinsons Disease Carriers across Populations from the Global Parkinsons Genetics Program
Objective: To identify genetic risk modifiers for GBA1 risk variant carriers of European and African ancestry, we used data from GP2 (http://gp2.org/), the UK Biobank,…Developing a Unified Advanced Neuromodulation Clinical Pathway for MR-Guided Focused Ultrasound and Deep Brain Stimulation
Objective: To analyze determinants of neuromodulation treatment selection, including patient preferences and clinical eligibility, in a large real-word cohort of patients diagnosed with Parkinson’s Disease (PD) and Essential…Identifying Peripheral Stimulation Sites to Treat Parkinson’s Disease Gait Impairments
Objective: Our aim is to develop a non-invasive treatment for Parkinson’s Disease gait symptoms by applying peripheral stimulation to the feet using coordinated reset stimulation…Resting-state network reorganization following multimodal lifestyle intervention in Parkinson’s disease
Objective: To investigate longitudinal changes in resting-state (rs) functional connectivity following a multimodal lifestyle intervention in individuals with Parkinson's disease (PD). Background: PD is associated with disruption of large-scale…Macrophage Subtypes in Brainstem Catecholamine Regions in Healthy Ageing and Across Parkinson’s Disease.
Objective: To assess macrophages in the human brainstem in healthy ageing and during Parkinson’s disease (PD). Background: PD is the second most common neurodegenerative disorder…Efficacy of Combining Outpatient Palliative Care with Standard Care on Quality of Life and Caregiver Burden in Atypical Parkinsonian Syndrome – A Randomised Controlled Trial
Objective: This study evaluates the effectiveness of structured outpatient palliative care combined with standard care compared to standard care alone at 3 and 6 months…Severe Gastroparesis and Atypical Parkinsonism as Presenting Features of Neuronal Intranuclear Inclusion Disease (NIID)
Objective: To report a case of adult-onset neuronal intranuclear inclusion disease (NIID) presenting with progressive gait instability, neurogenic bladder, and life-threatening gastrointestinal dysmotility. Background: NIID…Adult hippocampal neurogenesis and cognitive and neuropsychiatric symptoms in Parkinson’s disease: the MemHiN study
Objective: To examine associations between serum-derived adult hippocampal neurogenesis (AHN)1 markers and cognitive and neuropsychiatric symptoms in Parkinson’s disease (PD), and to explore whether a…Low-dose ketamine reduces dopamine 2 receptor-like agonist-induced dyskinesia in a preclinical model
Objective: Preclinical evaluation of low-dose ketamine treatment on dyskinesia induced by direct or indirect striatofugal pathway activation. Background: Ketamine infusions are effective therapy for depression…Cortical–Subcortical Structural Signature of dementia with lewy bodies Reveals Cognitive Trajectories of Lewy Body Disease in REM Sleep Behavior Disorder
Objective: We aimed to derive a DLB-related structural MRI pattern based on cortical and subcortical morphometry and investigate whether this pattern predicts phenoconversion and clinical…
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