Comparative Motor Response to Bilateral STN‑DBS in LRRK2‑Related and Idiopathic Parkinson’s Disease
Objective: To compare motor improvement after subthalamic nucleus deep brain stimulation (STN‑DBS) in patients with LRRK2‑associated Parkinson’s disease (PD) versus idiopathic PD (iPD). Background: LRRK2…Rare Variant Analysis in Parkinson’s Disease Patients Stratified by Polygenic Risk
Objective: To identify rare variants that may contribute to Parkinson’s disease (PD) risk in individuals whose polygenic background does not adequately explain their disease status.…Escitalopram for Depression and Motor Symptoms in Parkinson’s Disease: A Systematic Review and Meta‑analysis
Objective: To evaluate the efficacy of escitalopram versus placebo for depressive symptoms, motor severity, and quality of life (QoL) in Parkinson’s disease (PD). Background: Depression…Genetic Variation in KCNJ6 Gene Increases Risk of Impulse Disorders in Parkinson’s Disease: A Two-Cohort Study
Objective: To investigate the association between polymorphisms related to reward and punishment processing, and the development of impulse control disorders (ICDs) and compulsive behaviors (CBs)…Video-Based Gait Analysis for Objective Assessment of Motor Severity and Surgical Outcome in Parkinson’s Disease: A Scalable Alternative to Subjective Rating
Objective: To evaluate the accuracy of a gait-focused video analysis model in predicting clinical scores and post-surgical improvement in Parkinson’s disease (PD) Background: The MDS-UPDRS…Therapeutic Efficacy of a Next-Generation 16-Contact Directional Deep Brain Stimulation System in Parkinson’s Disease
Objective: We assessed the clinical efficacy and safety of a novel deep brain stimulation (DBS) system equipped with 16-contact directional leads in improving motor symptoms…Regional Homogeneity in the Visual Network Mediates between Microbiota and Cognition in Parkinson’s Disease
Objective: We study the role of spontaneous brain activity in the cross-talk between gut microbiota and cognition in PD. Background: Gut dysbiosis is a prevalent…Intrinsic Suppression of the NRF2–Ferroptosis Defense Axis Defines Selective Vulnerability of D2-Striosome Neurons in Huntington’s Disease
Objective: This study mapped baseline stress-response and cell death programs in healthy human striatal populations to identify intrinsic molecular constraints in D2-striosome neurons and their…Do Digital Mobility Outcomes Differ Across Clinically Defined NSD-ISS Stages in Parkinson’s Disease?
Objective: To determine whether digital mobility outcomes (DMOs) differ between individuals with relatively advanced PD grouped according to the clinical criteria of the Neuronal α-Synuclein…Evaluating YouTube as a source of health information on Parkinson’s disease
Objective: This study aimed to evaluate the quality, reliability, and engagement characteristics of YouTube videos on Parkinson's disease using standardized assessment tools. Background: Parkinson’s disease…
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