FUS R521S mutation causing levodopa responsive amyotrophic lateral sclerosis-Parkinson’s disease (ALS-PD).
Objective: The coexistence of Parkinson's disease (PD) and ALS is uncommon. This overlap syndrome, characterized by levodopa-responsive parkinsonism in the context of ALS, has been…Clinical progression of PSP-Richardson’s syndrome and other PSP variants in an East Asian cohort
Objective: This study aimed to compare longitudinal clinical progression between patients with progressive supranuclear palsy–Richardson syndrome (PSP-RS) and those with PSP-subcortical phenotypes. Background: PSP is…Automated Identification of Freezing of Gait in Parkinson’s Disease Using Q-Learning Analysis during Virtual Reality–Based Gait Task
Objective: To investigate whether a virtual reality (VR)-based gait task can induce freezing of gait (FOG) in Parkinson’s disease (PD) and whether gait trajectory data…Exploring a Milestone-Based Approach as an Outcome Measure for Disease-Modifying Parkinson Disease Trials
Objective: To replicate a composite milestone(CM) approach in a range of Parkinson Disease(PD) studies(observational, clinical trials) over a long time period(up to 12 years). To…The Diagnostic Value of Dopaminergic-Glucose United PET Imaging in Parkinson’s disease
Objective: This study aimed to evaluate the diagnostic efficacy of DAT-FDG united PET imaging in differentiating PD from other parkinsonian disorders in real-world clinical settings…Cross-trait and Multi-polytranscriptomic Score Prediction of Parkinson’s Disease
Objective: To integrate genome-wide association study summary statistics, expression quantitative trait loci (eQTL), individual-level RNA sequencing data and machine-learning approaches to identify molecularly informed cross-trait…Diffusion MRI Evidence of Cerebellar Involvement in Cognitive Dysfunction in Parkinson’s Disease
Objective: To determine whether cerebellar axonal microstructural abnormality is associated with cognitive performance in PD. Background: Cognitive impairment in Parkinson’s disease (PD) often affects executive…Amyloid PET–Guided Anti-amyloid Therapy in Corticobasal Syndrome Associated with Clinical Improvement
Objective: To clarify the clinical significance of amyloid positron emission tomography (PET) in patients presenting with corticobasal syndrome (CBS) and to describe the potential therapeutic…External Validation of a Machine Learning Classifier for Motor Progression in Parkinson’s Disease
Objective: To externally validate a previously published machine learning (ML) classifier for predicting motor symptom progression in Parkinson’s disease (PD) using an independent clinical dataset.…Cholinergic Pathway Degeneration Predicts Differential Phenoconversion to Synucleinopathies in Idiopathic REM Sleep Behavior Disorder
Objective: This cross-sectional and longitudinal study aimed to elucidate the pattern of cholinergic white matter pathway degeneration underlying the phenoconversion trajectories in iRBD patients. Background:…
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