Translating Real-World Parkinsonian Facial Kinematics onto Diverse Digital Avatars
Objective: To support the development of a smart textile with facial sensors and present a novel continuous monitoring approach, we derived and rendered digital twins…Levodopa–Entacapone–Carbidopa Intestinal Gel in Advanced Parkinson’s Disease: a Four-Year Real-Life Experience
Objective: To describe the improvement of motor complications in patients with advanced Parkinson’s Disease (APD) treated with Levodopa-Entacapone-Carbidopa Intestinal Gel (LECIG). Background: The continuous enteral…Fracture Burden and Health-Related Quality of Life in Older Adults with Parkinson’s Disease in Rural India: A Community-Based Study
Objective: This study aimed to examine the relationship between fracture history and health-related quality of life (HRQoL) among elderly individuals with Parkinson’s disease residing in…Microstructural cortical alterations are related to cognitive and disease severity in progressive supranuclear palsy
Objective: To study cortical microstructural alterations in patients with progressive supranuclear palsy (PwPSP) and their associations with both cognitive and clinical symptoms. Background: Midbrain’s atrophy on structural…Higher Dopaminergic Sensitivity Underlies Dyskinesia Occurrence in Indigenous Sabahan PRKN Parkinson’s Disease
Objective: To compare dyskinesia occurrence and associated factors in PRKN versus non-PRKN early-onset Parkinson's Disease (EOPD). Background: Biallelic pathogenic PRKN variants represent the commonest recessive…Boxing-Based Exercise Programs for Parkinson’s Disease: A Review of Motor and Quality-of-Life Outcomes
Objective: To evaluate the effects of boxing-based exercise interventions as an adjunct therapy for individuals with Parkinson’s disease (PD). Background: Parkinson’s disease is the second…Motion-Capture features associated with Outcome after MRgFUS Vim thalamotomy for Essential Tremor
Objective: To identify factors associated with outcomes after magnetic resonance-guided focused ultrasound (MRgFUS) ventral intermediate nucleus (Vim) thalamotomy using motion-capture analysis of tremor videos in…Responsiveness of Sensor-Derived Measures From a Smartphone-Based Active Typing Test in the Phase 2b LUMA Study of Parkinson’s Disease
Objective: Investigate the measurement properties of exploratory sensor-derived measures (SDMs) from a smartphone-based typing test in the LUMA study of BIIB122/DNL151 for Parkinson’s disease (PD).…Comparison Of Levodopa Dose Frequency And Parkinson’s Kinetigraph Metrics For Screening Advanced Parkinson’s Disease
Objective: 1. Evaluate how well levodopa dose frequency and Parkinson's Kinetigraph (PKG) metrics correspond with the 5-2-1 criteria for identifying Advanced Parkinson Disease (APD)2. Determine…An observational study of segmental and generalized isolated dystonia to inform development of new drug therapies
Objective: The goal of this study is to characterize severity and variability of symptoms in people with segmental, multifocal, or generalized isolated dystonia. Standardized data…
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