Cerebrospinal Fluid Markers are associated with Cognitive Decline in GBA1-associated Parkinson’s Disease
Objective: To analyze whether and how cerebrospinal fluid (CSF) amyloid-related markers relate to the longitudinal cognitive profile in PD-GBA1. Background: Cognitive decline in Parkinson’s disease…Does Fall-Related Activity Avoidance Differ between people with Parkinson’s disease versus Cognitively Unimpaired Controls?
Objective: investigate whether fall-related activity avoidance differs between people with Parkinson’s disease (PD) versus cognitively unimpaired controls (CU) without any significant neurological disease. Background: Although…Development and preliminary results of a new self-assessment tool for neuropsychiatric syndromes in Parkinson’s Disease
Objective: To develop a self-report screening tool for neuropsychiatric syndromes (NPS) in patients with Parkinson’s Disease (PD) and to conduct an initial evaluation of its…Stakeholder Engagement to Inform Research on Suicidality and Assisted Dying in Parkinson’s
Objective: To explore stakeholder perspectives to identify shared research priorities on suicidality and assisted dying in Parkinson’s and co-design subsequent research. Background: People with Parkinson’s…When Presynaptic Stimulation is Not Enough: Severe Biphasic Dyskinesia on LECIG Reversed by Postsynaptic Apomorphine Rescue
Objective: To report an exceptional case of advanced Parkinson’s disease (PD) where levodopa/carbidopa/entacapone intestinal gel (LECIG) failed to provide adequate motor control, ultimately requiring a…Single stage Dual target Deep Brain Stimulation for Dystonic Tremor
Objective: Choosing the right target for deep brain stimulation surgery for dystonic tremor can be tricky. Patients usually treated by VIM-DBS or GPi-DBS. Dual targeting is…Midbrain Organoid Modeling and Transcriptomic Characterization of NOTCH2NLC GGC Repeat Expansion–Associated Parkinson’s Disease
Objective: To characterize transcriptomic alterations in patient-derived midbrain organoids carrying NOTCH2NLC GGC repeat expansions and assess their relevance to canonical Parkinson's disease (PD) mechanisms. Background:…The Dual Functional Organization of the Substantia Nigra in Parkinson’s Disease
Objective: We applied connectopic mapping to the internal functional organisation of the substantia nigra (SN) in independent cohorts. Background: The human SN is a central…A Novel Therapeutic Targeting the tPA-NMDAr Interaction for Multiple System Atrophy
Objective: LYS241, a first-in-class, humanized, and optimized monoclonal antibody, designed to inhibit the interaction between tissue plasminogen activator (tPA) and N-methyl-D-aspartate receptor (NMDAr), has demonstrated…Validation of the Chinese Version of the Unified Multiple System Atrophy Rating Scale
Objective: To assess the psychometric properties of the Chinese version of the Unified Multiple System Atrophy Rating Scale (UMSARS). Background: The UMSARS is the gold‑standard…
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