Non-Motor Symptom Improvement as a Driver of Quality of Life after Subthalamic Stimulation in Symmetric Parkinson’s Disease
Objective: To investigate non-motor outcomes in patients with symmetric vs. asymmetric motor symptoms following subthalamic stimulation (STN-DBS) in Parkinson’s disease (PD). Background: Motor asymmetry is…Integrating Transcriptomics and Morphological Profiling to Characterize GBA-Associated Parkinson’s Disease in Midbrain Organoids
Objective: This study characterizes converging biological trends in GBA-associated Parkinson’s Disease by integrating transcriptomic profiling with exploratory image-based analysis of donor-matched midbrain organoids. Background: High-content…Enteric Alpha-Synuclein Pathology in Early-Onset Parkinson’s Disease and an Incidental Case in Spinocerebellar Ataxia Type 6
Objective: This study aimed to investigate Alpha-synuclein (AS) accumulation in the gastrointestinal (GI) tract of patients with early-onset PD (EOPD). Background: AS accumulation is found…Harnessing the Local Wisdom of Central Kalimantan’s Eleutherine palmifolia (Dayak Onion) in Parkinson’s Disease Therapy: A Molecular Docking and Ethnopharmacological Study”
Objective: The purpose of this in silico study was to examine the potential protective effects of chemicals found in dayak onion against PD Background: Dayak…Ultra-early Diagnosis of MSA-C Using Biological Biomarkers: A Two-Case Study Employing α-Synuclein PET and Fluid α-Synuclein Seeds Amplification Assay (SAA)
Objective: To report cases in which combined α-synuclein PET and body fluid α-synuclein seeds amplification assay (SAA) enabled biological diagnosis of multiple system atrophy–cerebellar type…Video-Nystagmographic Biomarkers of Oculomotor Dysfunction in Parkinson’s Disease: Correlation With Motor Severity and Cognition
Objective: To quantitatively evaluate oculomotor dysfunction using video-nystagmography (VNG) in patients with Parkinson’s disease (PD) and determine its association with motor severity, disease duration, and…Multimodal Imaging in Cervical Dystonia with Botulinum Toxin Treatment: A Pilot 5.0T MRI and 99mTc-MIBI SPECT/CT Study
Objective: To comprehensively investigate structural, vascular, and metabolic alterations in cervical dystonia (CD) patients using ultra-high-field 5.0T magnetic resonance imaging (MRI) and 99mTc-MIBI SPECT/CT. Background:…Presence of Common Psychiatric Diagnoses Did Not Impact the Efficacy or Safety of Ecopipam in Individuals With Tourette Syndrome
Objective: To evaluate ecopipam efficacy/safety in individuals with Tourette syndrome (TS) with or without common psychiatric comorbidities. Background: Co-occurring psychiatric conditions are frequently observed with…Characteristics of participants of the Australian National Disability Insurance Scheme with Parkinson’s disease
Objective: To evaluate the demographic characteristics, goals and funding of participants with Parkinson’s disease (PD) in the Australian National Disability Insurance Scheme (NDIS). Background: The…Functional Improvement Following Early GPi-DBS for Moderate-Stage Atypical KMT2B Dystonia: A Case Report in a 13-Year-Old Girl
Objective: To report clinical trajectory and functional improvement of a child with atypical KMT2B-related dystonia following bilateral GPi-DBS performed at a moderate disease stage. Background:…
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