Stellate Ganglion Block for Restless Legs Syndrome in a Patient with Renal Failure a Case Report
Objective: To report a case of refractory restless legs syndrome (RLS) in a hemodialysis patient with renal failure who achieved significant symptom and sleep improvement…Rest Tremor does Not Predict Response to Focused Ultrasound Thalamotomy in Essential Tremor and Dystonic Tremor
Objective: To investigate whether pre-treatment rest tremor severity predicts outcomes in a cohort of patients with essential tremor/essential tremor plus (ET/ET+) and dystonic tremor (DT).…A Novel Genome Editing Strategy for Permanent and Precise Downregulation of α-Synuclein in Parkinson’s Disease
Objective: This work aims to develop and evaluate novel nonviral CRISPR-based genome editing strategies to achieve precise and durable transcriptional modulation of SNCA, enabling controlled…Multi-Sequence MRI-Based Machine Learning Model for Differentiating Parkinson Disease (PD) from Multiple System Atrophy (MSA)
Objective: To develop a multi-sequence MRI-based machine learning model differentiating PD from MSA. Background: MRI protocols capable of distinguishing PD from MSA are greatly needed.…Clinical Markers of Monogenic Mimics in Atypical Parkinsonism: Findings From a 150-Patient Series
Objective: We aimed to (1) define the yield and spectrum of genetic findings in an unselected Atypical Parkinsonism (AP) series and (2) identify clinical markers…High Frequency of Pathogenic Variants in Neurodevelopmental Genes in Patients with Dystonia
Objective: To systematically investigate the occurrence of pathogenic variants in genes linked to neurodevelopmental disorders (NDD) in patients with dystonia. Background: Partially overlapping genetic causes…Robot-Assisted Transplantation of Hypoimmune iPSC-Derived Dopaminergic Progenitor Cells for PRKN-EOPD
Objective: This study aimed to evaluate the safety and preliminary efficacy of NCR201 transplantation in a PRKN-EOPD patient, providing a first proof-of-concept for this hypoimmune…A Specific Neuronal Subpopulation in Globus Pallidus External Segment Mediates the Pathogenesis of Dyskinesia in Parkinson’s Disease
Objective: To clarify the causality between neuronal activity in globus pallidus external segment (GPe) and levodopa-induced dyskinesia (LID), and further ascertain the specificity of this…Severity of Psychotic Symptoms Is Independently Associated with Caregiver Burden in Parkinson’s Disease: A Cross-Sectional Analysis
Objective: To evaluate the association between psychotic symptom severity and caregiver burden in patients with PD. Background: Psychotic symptoms are common in Parkinson’s disease (PD)…Multicenter Evaluation of Automated Structural MRI-based Diagnosis for Multiple System Atrophy
Objective: This study aims to evaluate whether automated classification based on individual voxel-based morphometry (VBM) adjusting covariates (iVAC) can achieve high diagnostic accuracy for MSA…
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