High-dimensional proteomic profiling in plasma and CSF identifies molecular signatures in Parkinson’s disease
Objective: To characterise Parkinson’s disease (PD)-related proteomic profiles in plasma and cerebrospinal fluid (CSF), to assess differential expression between PD and healthy controls (HC), along…Global Performance Patterns in the MDS-UPDRS Motor Certification Program: A five-year Analysis
Objective: To evaluate participation trends, certification rates, case-level difficulty, and item-level performance patterns over five years. Background: The MDS-UPDRS Part III is a core outcome…Foslevodopa-Foscarbidopa Continuous Subcutaneous Infusion Leads to Long-Term Reduction in Dyskinesia in Parkinson’s Disease: Results from 5-Year Follow-Up
Objective: To investigate the long-term impact of foslevodopa-foscarbidopa continuous subcutaneous infusion (CSCI) on dyskinesia in Parkinson’s disease (PD). Background: Foslevodopa-foscarbidopa CSCI is an emerging treatment…Creutzfeldt Jakob Disease Miming a Cortico-basal syndrome: does it exist?
Objective: Our objective is to report a rare and unusual association and assess the plausibility of sporadic Creutzfeldt‑Jakob disease as an underlying cause of corticobasal…Shared and Sex-Specific Genetic Risk for Parkinson’s Disease Across European Populations
Objective: To investigate sex-specific autosomal genetic factors associated with PD risk. Background: Parkinson’s disease (PD) affects females and males differently, with differences in prevalence, clinical…Disentangling Disease- and Medication-Associated Gut Microbiome Signatures in Parkinson’s Disease
Objective: To determine how Parkinson’s disease (PD) medications influence gut microbiome composition and function, and to distinguish microbiome features associated with PD pathology from those…Pueraria tuberosa improves the locomotion defects in Drosophila model of FRDA
Objective: To study the therapeutic potential of the medicinal herb Pueraria tuberosa on Drosophila model of Friedreich’s ataxia. Background: Reduced levels of the mitochondrial protein…The Therapeutic Landscape of SSPE: A Systematic Review of Antiviral and Immunomodulatory Modalities
Objective: To systematically map the global therapeutic landscape of SSPE interventions, specifically characterizing drug regimens, dosages, administration routes, and monotherapy versus combination protocols. Background: SSPE…Cerebellar Non-Invasive Brain Stimulation for Tremor Reduction in Essential Tremor: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Objective: To evaluate the safety and efficacy of cerebellar NIBS for tremor reduction inpatients with ET. Background: Essential tremor (ET) is generally managed pharmacologically, but…Prevalence and characteristics of sleep disorders in Parkinson’s disease: an Argentine cohort.
Objective: To evaluate the prevalence, severity, and clinical correlates of sleep disturbances in patients with Parkinson’s disease (PD) using validated sleep assessment scales and questionnaires.…
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