Subthalamic Nucleus Oscillatory Coupling During Sleep is Impaired in Parkinson’s Disease and Associated with Memory Consolidation
Objective: To investigate whether the subthalamic nucleus (STN) supports sleep-dependent memory consolidation through hierarchical oscillatory coupling, and whether this mechanism is disrupted in Parkinson's disease…Long-term safety of deep brain stimulation (DBS): Real-world evidence
Objective: In this analysis, we aimed to evaluate long-term safety of DBS systems in real-world use. Background: Deep brain stimulation (DBS) is an established therapy for…Temporal Interference Stimulation of Dentate Nucleus Suppressed Essential Tremor
Objective: To assess the effect of 7-session transcranial temporal interference stimulation(tTIS) targeting dentate nucleus (DN) in people with essential tremor (ET). Background: ET is a…Genetic spectrum of spinocerebellar ataxia type 27b (atx-fgf14-gaa): a single-center study
Objective: To describe the genetic spectrum of (GAA)n-expansions in the FGF14 gene (size and structural repeats) associated with SCA27B in Slavic patients. Background: The genetic…Analysis of Genetic Variants Associated with Parkinson’s Disease and Depression
Objective: The objective of this study was to evaluate the effect of SNPs in BDNF on depressive symptomatology in a sample of individuals with PD.…Attention-Enhanced Deep Learning for Midbrain MRI Segmentation in Parkinson’s Disease
Objective: To develop an automated deep learning framework for robust midbrain segmentation in MRI data of Parkinson’s disease patients. Background: Structural alterations in the midbrain…FUS R521S mutation causing levodopa responsive amyotrophic lateral sclerosis-Parkinson’s disease (ALS-PD).
Objective: The coexistence of Parkinson's disease (PD) and ALS is uncommon. This overlap syndrome, characterized by levodopa-responsive parkinsonism in the context of ALS, has been…Clinical progression of PSP-Richardson’s syndrome and other PSP variants in an East Asian cohort
Objective: This study aimed to compare longitudinal clinical progression between patients with progressive supranuclear palsy–Richardson syndrome (PSP-RS) and those with PSP-subcortical phenotypes. Background: PSP is…Automated Identification of Freezing of Gait in Parkinson’s Disease Using Q-Learning Analysis during Virtual Reality–Based Gait Task
Objective: To investigate whether a virtual reality (VR)-based gait task can induce freezing of gait (FOG) in Parkinson’s disease (PD) and whether gait trajectory data…Exploring a Milestone-Based Approach as an Outcome Measure for Disease-Modifying Parkinson Disease Trials
Objective: To replicate a composite milestone(CM) approach in a range of Parkinson Disease(PD) studies(observational, clinical trials) over a long time period(up to 12 years). To…
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