Device-aided Therapies are Associated with Significantly Greater Improvement in Quality of Life in Younger Patients Earlier Within Advanced Parkinson’s Disease
Objective: To evaluate the impact on health-related quality of life (HRQoL) of treatment with device-aided therapies (DAT) in younger patients earlier within advanced Parkinson's disease…The Effect of LRRK2 and GBA1 Mutations on Survival in Early- and Late-onset Parkinson’s Disease
Objective: Survival assessment of PD patients genetically tested at Tel-Aviv Sourasky Medical Center between 2005-2025. We hypothesize that LRRK2-PD would show higher survival rates compared…Intravenous AAVrh.10hFXN (LX2006) Gene Therapy in Friedreich Ataxia: Early Neurologic Assessment from Two Phase 1 and 2 Studies
Objective: To evaluate neurologic measures of efficacy of intravenous AAVrh.10hFXN (LX2006) gene therapy in adults with Friedreich ataxia, based on data from the SUNRISE-FA study…Does Balance Mediate the Relationship Between Aerobic Capacity and Walking Endurance in Parkinson’s Disease?
Objective: To examine whether balance mediates the relationship between aerobic capacity and walking endurance in individuals with Parkinson’s disease (PD) Background: Impaired walking capacity contributes…Sex differences for clinical impact of APOEe4 mediated by Alzheimer’s pathology in people with Lewy body pathology
Objective: Assess whether Alzheimer’s (AD) or Lewy body (LB) pathologies mediate the association between APOEe4 and clinical profile differently for females and males with LB…Digital cognitive training and promoting a healthy lifestyle as a booster for cognitive reserve in prodromal Parkinson’s disease?
Objective: To investigate predictors of responsiveness to a multimodal cognitive training intervention in individuals with isolated REM sleep behavior disorder (iRBD). Background: The prodromal phase…Efficacy of Opicapone in Early Motor Fluctuations in Parkinson’s Disease: A Comparison of Early versus Later Initiation
Objective: This post-hoc analysis assessed the long-term outcomes of early initiation of opicapone in levodopa-treated patients with early wearing-off in Parkinson’s disease. Background: The best…The Anxiolytic Effect of Cannabidiol and Tetrahydrocannabinol in a Reserpine Model of Parkinson’s Disease in Mice
Objective: This study evaluated the anxiolytic effects of CBD, THC, and their combination in a reserpine-induced Parkinson’s mouse model using the Elevated Plus Maze (EPM)…Cognitive Impairment and Neuropsychiatric Manifestations in Parkinson’s disease in Africa: A Systematic Review of Evidence
Objective: To critically appraise and synthesize evidence on the prevalence and clinical correlates of cognitive impairment and neuropsychiatric manifestations among patients with Parkinson’s disease in…Investigating Substantia Nigra Microstructural Integrity as a Potential Predictive Biomarker for Fall Burden in Parkinson’s Disease
Objective: Determine whether baseline Diffusion Tensor Imaging (DTI) measures of the substantia nigra (SN) predict fall incidence and burden in Parkinson’s disease (PD). Background: Degeneration of dopaminergic…
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