Pharmacological PGC-1α Activation Mitigates Dopaminergic Degeneration in Parkinson’s Disease Via Regulating Mitochondrial Homeostasis
Objective: To understand the role of mitochondrial function in improving the outcomes of Parkinson’s disease (PD) via pharmacologically activating PGC-1α by its synthetic activator ZLN005.…Establishing a Timeline of Non-Motor and Motor Symptoms Progression in Parkinson’s Disease Using a Sub-Chronic MPTP Mouse Model
Objective: Parkinson’s disease (PD) mouse model using 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was explored for pathological mechanisms driving non-motor symptoms (NMS). Aim was to map the behavioural changes…Protective effects of Hesperidin loaded polymeric nanoparticles on the progression of MPTP Induced Parkinson’s disease via targeting GPR43/NLRP3 signaling pathway: in vitro and in vivo studies
Objective: Emphasizing the G protein-coupled receptor 43 (GPR43) and the NLRP3 signaling pathway in both in vitro and in vivo models, this work studies the…Investigating the Neuroprotective Potential of Mushroom Extracts in Parkinson’s Disease In Vitro Models
Objective: This study aims to evaluate the neuroprotective potential of various mushroom extracts in in vitro models of PD. Background: Parkinson’s disease (PD) is a…Dietary Caffeic Acid Exhibits Neuroprotective and Neuromodulatory Effects in a Parkinsonian Rat Model by Mitigating Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis
Objective: This study investigated the neuroprotective and neuromodulatory effects of dietary caffeic acid (CA) in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonian rat model Background: Parkinson’s disease (PD)…SARS-CoV-2 induced neurodegeneration in oxidative stress and genetic models of Parkinson’s Disease
Objective: Given similarities in systemic responses after infection with SARS-CoV-2 to those reported after the 1918 pandemic, we investigated whether SARS-CoV-2 could elicit a similar…The Neuroprotective Effects of Rolipram, a Selective Phosphodiesterase IV Inhibitor, on Parkinson’s Disease in Rat Models: A Pharmacological Exploration in both In vivo and In vitro Settings
Objective: Our research sought to unravel the pharmacological effects and mechanisms of action of Rolipram through both in vivo and in vitro experimentation in models…Design, synthesis and pharmacological evaluation of 16-pyridylmethylene derivatives of steroidal oximes as antiparkinsonian agents in MPTP-injected mice.
Objective: The objective of the present study is focused on the design and synthesis of 16-pyridyl methylene derivatives of steroidal oximes and further their pharmacological…Differences in Molecular and Ultrastructural profiles of astroglia and microglia in substantia nigra of two different mice strains in normal aging and experimental Parkinsonism
Objective: To examine whether the variable sensitivity of dopaminergic neurons of the substantia nigra pars compacta -SNpc- in C57BL/6J and CD-1 mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/ MPTP…Impact of sub-acute MPTP exposure on the cerebellum in adult male Balb/c mice
Objective: The objective of the study was to investigate the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration on the cerebellum of adult male Balb/c mice Background: Parkinson’s…
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