Neuroprotection and Alleviation of Parkinsonian Phenotypes by Ayurvedic Herbs
Objective: Our laboratory has focused on the herbal treatment of Parkinson’s disease especially by the above two common herbs Withania somnifera (Ws) and Mucuna pruriens…Piperine potentiate the neuroprotective effect of quercetin against MPTP induced neurotoxicity in rats
Objective: (1) Quercetin is well tolerated bioflavonoid used as supplement for various disorders but problem is its low oral bioavailability and (2) Piperine is combined…Study of neuroprotective effects of Ginsenside Rg3 , the prototypal epigenetic Sirtuin-1 activator, in targeting microglia activation and neurotrophic factor (NF) neural plasticity in MPTP model of Parkinson’s disease (PD)
Objective: 1) to examine whether the phyto-neurosteroid: Ginsenoside Rg3 recently demonstrated to activate the epigenetic SIRTI signaling, will rescue the motor impairment in rodent model…Effects of Arachidonyl-2′-chloroethylamide (ACEA), a selective CB1 receptor agonist, in MPTP mouse model of Parkinson’s disease
Objective: Cannabinoids have been demonstrated to be effective in preclinical studies involving oxidative stress, neuroinflammation, and motor complications associated with Parkinson's disease (PD).The CB1 cannabinoid…The regulation of ASIC1a on dopamine release and its implication in the pathogenesis of Parkinson’s disease
Objective: To study the distribution of acid-sensing ion channel 1a (ASIC1a) in dopaminergic neurons and its role in regulating dopamine release, and to explore its…Piperine potentiates neuroprotective effect of curcumin in MPTP model of Parkinson’s disease in rats: Impact on neurochemical modulation
Objective: (1) Curcumin is well tolerated phenolic compound used for CNS disorder but problem is its low oral bioavailability and (2) Piperine is combined to…Hydrogen sulfide functions as a neuromodulator to regulate striatal neurotransmission in a mouse model of Parkinson’s disease
Objective: To Evaluate:prepared a MPTP/p induced mouse subacute model of PD, and explore the modulatory effect of H2S on monoamine and amino acid neurotransmitters in…Exercise-induced adaptive neuroplasticity in the MPTP mouse model of Parkinson’s disease
Objective: To increase our understanding of how physical exercise may drive adaptive neuroplasticity in a mouse model of Parkinson's disease (PD). Background: PD is a…
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