Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To Evaluate:prepared a MPTP/p induced mouse subacute model of PD, and explore the modulatory effect of H2S on monoamine and amino acid neurotransmitters in the striatum of MPTP treated mice. whether H2S can function as a neuromodulator to regulate the levels of nigrostriatal neurotransmitters and then impact the vulnerability of DA neurons in response to neurotoxins.
Background: H2S is a novel endogenous gasotransmitter,has been considered a neuromodulator to enhance hippocampal long-term potentiation and exerts neuroprotective effects against neurotoxin-induced neurodegeneration in rodent models of PD. However,whether H2S can function as a neuromodulator to regulate the levels of nigrostriatal neurotransmitters and then impact the vulnerability of DA neurons in response to neurotoxins remains unknown.
Methods: Immunohistochemical Quantitative Evaluation: Nissl1 and GFAP1 cells that were characterized by immunoreactive substances in the cytoplasm were all counted.High-Performance Liquid Chromatography:The levels of amino acids were measured by HPLC with fluorescence detection after precolumn derivatization with ophtaldialdehyde.
Results: H2S Improved the Survival Rate and Amelioratedthe Weight Loss of MPTP-Treated Mice. NaHS Inhibited MPTP-Induced Astrocytic Activation in the Mouse Striatum. NaHS Alleviated MPTP-Induced Neuronal Loss inthe Mouse Striatum. 4,NaHS Elevated Striatal 5-HT Levels in Responseto MPTP Injections. 5,NaHS Modulated Amino Acid Neurotransmittersin the Striatum of MPTP Mice.
Conclusions: This study shows that NaHS administration improves the survival rate and significantly ameliorates the weight loss of MPTP treated mice. NaHS treatment attenuated MPTP-induced neuronal damage, restored the diminution of DA neurons,and suppressed the overactivation of astrocytes in the mouse striatum. Additionally, NaHS upregulated striatal serotonin levels and modulated the balance of excitatory glutamate and the inhibitory g-aminobutyric acid system in response to MPTP challenge.
Indicates that H2S functions as a neuromodulator to regulate neurotransmission and provides insight into the potential of H2S for PD therapy.
To cite this abstract in AMA style:L. Zhang, M. Wang, J. Zhu, Y. Pan, J. Dong. Hydrogen sulfide functions as a neuromodulator to regulate striatal neurotransmission in a mouse model of Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/hydrogen-sulfide-functions-as-a-neuromodulator-to-regulate-striatal-neurotransmission-in-a-mouse-model-of-parkinsons-disease/. Accessed March 5, 2024.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/hydrogen-sulfide-functions-as-a-neuromodulator-to-regulate-striatal-neurotransmission-in-a-mouse-model-of-parkinsons-disease/