Lewy Pathology correlates with neuroinflammation in the hippocampus of Synucleinopathy patients in a subregion specific manner
Objective: The objective of this study is to examine the sub-regional differences in neuroinflammation (NI) in response to Lewy pathology (LP) within the hippocampus of…Targeted Brain Delivery of Rifampicin via PEG-PLA Nanoparticles: A Promising Therapeutic Strategy for Neuroprotection and Disease Modification in Parkinsonian Mouse Models
Objective: This study aimed to design and validate a nanoparticle-based delivery system for rifampicin, with the objective of enhancing its therapeutic efficacy, improving brain targeting,…Cerebrospinal fluid measured α-synuclein is related to metabolite profile in the serum and CSF
Objective: Determine metabolites associated with cerebrospinal fluid (CSF) measured α-synuclein (α-syn) using untargeted metabolomics measured in the serum and CSF. Background: Several large studies have…Blood-based biomarkers for diagnosis and prediction of Parkinson’s Disease in GBA1 individuals
Objective: To investigate glucocerebrosidase (GCase) enzymatic activity and different forms of α-synuclein (aggregated -Asyna – and monomeric - Asynm) in peripheral blood mononuclear cells (PBMCs)…Early Indicators of Alpha-synuclein Aggregation: Can Autonomic and Cognitive Markers Predict Prodromal Parkinson’s Disease?
Objective: To develop a model that predicts alpha synuclein (a-syn) status of patients at risk of Parkinson’s disease (PD) using non-motor and cognitive tests that…Effect of Aβ on α-synuclein propagation
Objective: To investigate how amyloid-beta (Aβ) pathology affects α-synuclein (α-syn) propagation. Background: Lewy bodies, the pathological hallmark of Parkinson’s disease and dementia with Lewy bodies,…Path To Prevention (P2P) Therapeutics Platform Trial in Stage 2B Neuronal Alpha-Synuclein Disease: Study Update
Objective: To describe the study design and timeline of the first interventional study in Neuronal α-Synuclein Disease (NSD). Background: P2P is a platform, Phase 2…Baseline NSD-ISS stage predicts long term progression and survival in sporadic PD: 10-year PPMI data analysis
Objective: To analyze long term progression in Neuronal Synuclein Disease (NSD) participants who were originally enrolled in the sporadic Parkinson Disease (sPD) cohort in PPMI…Chronic Sleep Fragmentation Accelerates the Onset of Prodromal Symptoms and Pathology in Parkinson’s Disease Model Mice
Objective: To investigate whether chronic sleep fragmentation accelerates the onset of prodromal symptoms and pathology of Parkinson’s disease (PD) in mice. Background: The prodromal phase…IGF2 Induce Neuroprotection in PD Preclinical Models by Modulation of Immune Response.
Objective: We propose to determine a therapeutic strategy based on adoptive transfer of macrophages reprogrammed for recombinant IGF2 (rIGF2) treatment in PD preclinical model. Background:…
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