Determining Cerebrospinal Fluid Alpha-Synuclein Seed Amplification Assay Status from Demographics and Clinical Data
Objective: To develop models that determine likeliness of positive detection of pathologic alpha-synuclein (asyn) in cerebrospinal fluid (CSF) as measured by seed amplification assay (SAA)…Unveiling the Link: Insulin’s Novel Role in Modulating α-Synuclein Accumulation in Parkinson’s Disease
Objective: This study marks the inaugural attempt to investigate the direct effects of insulin on pathological α-synuclein accumulation induced by the addition of α-synuclein preformed…Comparison of Age, Cognitive, Autonomic, and Motor Testing between Serotonergic vs Idiopathic REM-Sleep Behavior Disorder
Objective: To compare the age, cognitive, autonomic, and motor function of REM-Sleep Behavior Disorder (RBD) patients amongst those who believe their symptoms were triggered by…The Impact of VPS35 D620N Mutation on Alternative Autophagy and its Reversal by Estrogen in Parkinson’s Disease
Objective: We investigated the relationship between alternative autophagy and VPS35 D620N mutant-related PD pathogenesis. Background: VPS35 is critically involved in the mechanisms of neurodegeneration observed…Distinct Gut Microbiome in Parkinson’s disease Based on the Presence of Premotor Rapid-Eye Movement Sleep Behavior Disorders: Exploring the Alpha-synuclein
Objective: We aim to investigate the microbiome composition and functional profiles in Parkinson’s disease (PD) patients with and without premotor rapid eye movement sleep behavior…The potential role of monocytes a-synuclein and lipids as predictors of PD.
Objective: To study the role monocytic A-syn and lipids as biomarkers of PD. Background: A chronic pro-inflammatory pattern is present in Parkinson’s disease (PD) patients’…Path To Prevention (P2P) Therapeutics Platform Trial in Stage 2B Neuronal Alpha-Synuclein Disease: Study Update
Objective: To describe the study design and timeline of the first interventional study in Neuronal α-Synuclein Disease (NSD). Background: P2P is a platform, Phase 2…Baseline NSD-ISS stage predicts long term progression and survival in sporadic PD: 10-year PPMI data analysis
Objective: To analyze long term progression in Neuronal Synuclein Disease (NSD) participants who were originally enrolled in the sporadic Parkinson Disease (sPD) cohort in PPMI…Chronic Sleep Fragmentation Accelerates the Onset of Prodromal Symptoms and Pathology in Parkinson’s Disease Model Mice
Objective: To investigate whether chronic sleep fragmentation accelerates the onset of prodromal symptoms and pathology of Parkinson’s disease (PD) in mice. Background: The prodromal phase…IGF2 Induce Neuroprotection in PD Preclinical Models by Modulation of Immune Response.
Objective: We propose to determine a therapeutic strategy based on adoptive transfer of macrophages reprogrammed for recombinant IGF2 (rIGF2) treatment in PD preclinical model. Background:…
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