Alpha-synuclein aggregate pathology in the cranial sensorimotor system in a mouse model of Parkinson’s disease.
Objective: The goal of this study was to examine the effect of a potential underlying mechanism responsible for the complex voice deficits that exist in…Combining alpha-synuclein PET and seeded amplification assays to improve the diagnostic accuracy of Multiple System Atrophy of the Parkinsonian subtype (MSA-P)
Objective: To determine whether the combination of spatial (PET [18F]ACI-12589) and conformational (skin seed amplification assay; SAA) a-syn data aids the early differential diagnosis of…Cognitive Performance in Early Neuronal alpha-Synuclein Disease
Objective: To determine if cognitive deficits can be detected in early-stage Neuronal alpha-Synuclein Disease (NSD) compared with healthy controls. Background: Global cognitive deficits have been…Pathological Mechanisms Associated with Atrazine-Induced Parkinson’s Disease Pathogenesis in Rat Model: The Rescue Role of Myricetin
Objective: This study aimed at investigating the mechanisms involved in the pathogenesis of Parkinson’s Disease in atrazine rat model of Parkinson’s Disease and the neuroprotective…Polyamine pathways: a promising frontier for biomarkers and therapeutic targets in Parkinson’s disease (PD)
Objective: To systematically modulate polyamine (PA) metabolic pathways and investigate PA biomarker findings in PD using Drosophila melanogaster over-expressing human wild-type α-synuclein gene (hSNCA). Our…Tissue-Engineered Nigrostriatal Pathways: An Anatomically-Inspired Model of Synucleinopathy in Human Neurons
Objective: The objectives of this study were (1) to create a human cell-based three-dimensional neural network that recapitulates the discrete somatic and axonal compartments of…Identification of underlying Lewy body pathology in primary tauopathies by α-synuclein seed amplification assay
Objective: To determine intravitam prevalence of α-synuclein (αSyn) pathology in primary tauopathies, such as PSP and CBS, by αSyn seed amplification assay (synSAA) Background: Neuropathological…Investigating an Emerging Anxiety-like Phenotype in a Novel Bilateral Rodent Model of Parkinsonian Alpha-Synuclein Pathology
Objective: Investigate an emerging anxiety-like phenotype at various timepoints in a novel bilateral rodent model of parkinsonian alpha-synuclein pathology. Background: Parkinson’s Disease (PD) anxiety poses…Rora deficiency aggravates dopamine neurons loss via reducing NAD+ level in Parkinson’s disease
Objective: To investigate the mechanism by which retinoic acid-related orphan receptor alpha(RORα) regulates NAD+ levels to dopamine neuronal degeneration in Parkinson’s Disease (PD). Background: PD is an age-related degenerative…Cross-Omics Clustering Identifies Common Molecular Patterns in Parkinson’s Disease
Objective: Uncover novel molecular signatures to define Parkinson's disease (PD) patients' clusters using multi-omics integration and evaluate clinical and neuroimaging data. Background: PD is a…
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