Clinical profiles of late-onset psychiatric patients with incidental REM sleep without atonia
Objective: The clinical profiles of late-onset psychiatric patients exhibiting incidental REM sleep without atonia (RWA), which is a hallmark of REM sleep behavior disorder (RBD)…Fluvoxamine maleate effects on dopamine signaling in the prefrontal cortex of stressed parkinsonian rats: Implications for learning and memory
Objective: In the present study, we investigated the effects of reduced DA presence in the PFC on cognitive function and whether treatment with Fluvoxamine maleate…Fluvoxamine maleate normalizes striatal neuronal inflammatory cytokine activity in a Parkinsonian rat model associated with depression
Objective: The objective of this study was to investigate how fluvoxamine maleate treatment regulates depressive-like symptoms, motor impairments and the expressions of IL-1beta, IL-6, IL-10…Tardive syndromes induced by coadministration of tramadol and sertralin
Objective: To illustrate the possible association of tardive syndromes (TS) and coadministration of tramadol and sertraline in three patients. Background: TS is delayed onset of…The tricyclic antidepressant medication nortriptyline inhibits alpha-synuclein accumulation, aggregation and toxicity in multiple in vitro and in vivo models.
Objective: Using preclinical models, assess the potential disease-modifying effects of nortriptyline (NOR) as a treatment in early Parkinson’s disease (PD). Background: PD and other synucleinopathies…The clinically-available anti-depressant mirtazapine alleviates both psychosis and dyskinesia in the MPTP-lesioned marmoset
Objective: To determine the effect of mirtazapine, a clinically-available anti-depressant, on psychosis and dyskinesia in Parkinson’s disease (PD). Background: Psychosis and dyskinesia cause significant morbidity…Neuroprotective effects of antidepressant mirtazapine against dopaminergic neurodegeneration in cultured cells and in parkinsonian mice possibly by targeting astrocytes
Objective: In this study, we examined neuroprotective effects of mirtazapine and involvement of astrocytes in the effects using primary cultured cells and parkinsonian mice. Background:…Impaired hippocampal neurogenesis associates with serotonergic axonal degeneration in transgenic rat and mouse models of Parkinson’s disease
Objective: To evaluate the impact of α-synuclein accumulation on the hippocampal serotonergic system and hippocampal plasticity in two different α-synuclein expressing rodent models. Background: Parkinson's…The effects of fluvoxamine maleate in a post-natal stress rat model of neurodegeneration
Objective: In this study, we investigated whether treatment of anxiety-like symptoms with Fluvoxamine maleate alleviates the neurotoxic effects of 6-OHDA in a Parkinsonian rat model.…Effects of antidepressants on gait parameters in Parkinson’s disease
Objective: To compare GAITRite parameters between PD patients on antidepressants with patients who were not on any psychotropic. Background: PD patients have an increased risk…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.