Molecular Studies Reveal Overactive Interferon (IFN) Pathway in Two Monogenic Inherited Dystonia Types.
Objective: Our overall objective was to investigate the involvement of type I interferons (IFNs) in DYT-PRKRAand DYT-EIF2AK2. IFNs are antiviral cytokines produced by all cell…L1CAM and TMEM119 enriched Exosomal markers in Parkinson’s Disease and Progressive Supranuclear Palsy: A Prospective Study
Objective: This study explored longitudinal changes in cellular inflammatory, autophagic mediators in L1CAM and TMEM119-enriched exosomal samples of patients with Parkinson’s disease (PD) and Progressive…The Role of α7 Nicotinic Acetylcholine Receptor in Mitochondrial Homeostasis and Neuroprotection
Objective: This study aims to explore the neuroprotective role of α7 nicotinic acetylcholine receptor (α7nAChR) in mitochondrial homeostasis and its potential as a therapeutic target…Study of the functional role of circulating extracellular vesicles as mediators of inflammation in cellular models of Parkinson`s disease
Objective: To study mechanisms of cellular inflammation and neurodegeneration of EVs derived from patients with PD at different disease stages in cell-based disease models. Background:…Spinocerebellar ataxia type 2 specific microRNAs may have an effect on neurodegeneration.
Objective: 1.Identification of microRNA in whole blood PBMCs of SCA2 patients .2.Target prediction and pathway analysis of spinocerebellar ataxia type 2 identified miRNAs. 3.Validation of…the role of the “unfolded protein response” and the perk pathway in parkinson’s disease: study of genetic polymorphisms
Objective: To study a possible association between polymorphisms of the genes coding for proteins involved in the UPR and the development of PD or PD…Genetic and functional analysis of CCDC88C mutations in patients with Parkinson’s disease.
Objective: To investigate the association between rare deleterious CCDC88C variants and PD. Background: SCA40 is a rare form of spinocerebellar ataxia caused by heterozygous mutations…Silencing of hypoxia-inducible factor 1 alpha provokes a neuroprotective response in a SH-SY5Y model of Parkinson’s Disease.
Objective: Our study aims to delineate the role of HIF1α in a SH-SY5Y model of Parkinson’s disease (PD) Background: Parkinson’s disease (PD) is one of…Profile of miRNA expression in CSF of Parkinson’s disease identifies miR-409-3p regulating the apoptosis of dopamine neurons
Objective: To improve the precise diagnosis of PD at early stage requires more feasible and objective methods. MicroRNA (miRNA) was believed to be a potential…Neuroprotective effect of Lemon oil on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway
Objective: The objective of current investigation was to decipher e the neuroprotective effect of lemon oil (LO) on PC 12 cell lines by 6-hydroxydopamine (6-OHDA)…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.