Genetic and psychiatric risk factors for impulse control disorders in de novo Parkinson’s disease
Objective: To assess the interplay of polygenic dopamine risk scores and psychiatric symptoms in the development of impulse control disorders (ICDs) in de novo patients…Self-report vs. informant-report of problematic behaviors using the Huntington’s Disease-Behavioral Questionnaire
Objective: To examine the utility of a new behavioral measure, the Huntington’s Disease–Behavioral Questionnaire (HD-BQ) (Hughes et al, 2023), in individuals with Huntington’s disease (HD).…Impact of dopamine replacement therapy on shame in Parkinson’s disease patients
Objective: This study aims to investigate the effect of dopaminergic replacement therapy (DRT) on shame using emotional dynamic rating scales during ON and OFF-DRT states.…Evaluating the efficacy of dextromethorphan/quinidine (DM/Q) in treating irritability in Huntington’s disease
Objective: To prove the efficacy and safety of dextromethorphan/quinidine 20mg/10mg (Nuedexta®) in patients with irritability due to HD. Background: Irritability is one of HD's most…Needs and priorities of people with Parkinson’s and care partners regarding neuropsychiatric symptoms
Objective: To examine the experiences of people with Parkinson’s disease (PD) and care partners (CPs) regarding cognitive, mood, behavioral, and sleep issues. Background: Neuropsychiatric symptoms…Protective approach targeting NF-kB/ Nrf2 signaling and neuroinflammation using Apigenin in LPS induced Parkinsonism in experimental rats
Objective: 1. Apigenin as a protective strategy to prevent neuroinflammation in PD.2. To find behavioral, neurochemical and histopathological changes in LPS induced PD. Background: Parkinson’s…Cognitive and Motor aspects of a Brazilian population with Parkinson´s disease and Impulse Control Disorders and/or Related Behaviors – an observational study.
Objective: We analysed if Impulse Control Disorders (ICDs) and/or Related Behaviors (RBs) were associated with levodopa-induced dyskinesia (LIDs) in Brazilian patients with Parkinson´s disease (PD)…Contribution of external globus pallidus to motor deficits of Parkinson’s disease: optogenetic studies in murine model
Objective: The present study explored whether altered activity of external globus pallidus (GPe) neurons contributes to the development of motor deficits of Parkinson’s disease (PD).…Phantom Pregnancy – A Novel Impulse Control Behaviour in Parkinson’s Disease: A Case Report
Objective: A case report of a phantom pregnancy in a patient with Parkinson’s disease (PD) resulting from impulse control behaviour. Background: Impulse Control Disorders (ICDs)…Resting state functional brain networks associated with emotion processing in frontotemporal lobar degeneration
Objective: This study investigated the relationship between emotion processing and resting-state functional connectivity (rs-FC) of the brain networks in frontotemporal lobar degeneration (FTLD). Background: Defective…
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