Cost-utility analysis of flexible interval incobotulinumtoxinA versus onabotulinumtoxinA in the management of blepharospasm and cervical dystonia in Ontario, Canada.
Objective: To carry out a cost-utility analysis for IncoBTX administered with flexible treatment intervals compared to OnaBTX in the management of BL and CD from…Multiple Neural Networks dysfunction in Primary Blepharospasm: An Independent Components Analysis Study
Objective: This study aimed to explore altered functional brain connectivity and the possible correlations of these networks with clinical variables in BPS. Background: Primary blepharospasm (BPS) is a focal dystonia characterized by involuntary blinking and eyelid spasms. The pathophysiology of BPS remains unclear. Methods: Twenty-five patients with BPS and 25 age-and gender-matched healthy controls received resting-state fMRI scan. Group ICA was performed with the GIFT toolbox. Results: (1) There were no significant differences in the demographic variables between two groups besides the HAMA scores [table 1]. (2) Comparing with healthy control group, BPS patients exhibited different resting-state connections within sensory-motor network (SMN), right frontoparietal network (rFPN) and salience network (SN) [figure 1, figure 2]. BPS patients exhibited decreased connectivity within SMN that involved regions of the bilateral primary sensorimotor cortex, supplementary motor area, right superior frontal gyrus (BA 6), bilateral precuneus and left superior parietal cortex [table 2]. Within rFPN, decreased connections were observed in the middle frontal gyrus, DLPFC and inferior frontal gyrus [table 3]. Regarding salience network, increased connectivity was observed in the left superior frontal gyrus and middle frontal gyrus (including the DLPFC) [table 4]. We found positive correlation between the left superior frontal gyrus and HAMA scores, but this result was not significant. (3) Among the BPS patients, 12 performed sensory tricks positive (ST+), 9 perform sensory tricks negative (ST-). ST+ as compared to ST- patients exhibited significant higher connectivity in right premotor cortex within SMN [figure 3, table 5]. The results also showed a significant negative correlation between the right superior frontal gyrus and disease duration (Pearson's correlation r = -0.414, p = 0.038)[figure 4]. (4) We compared the SMN connectivity maps from pre- and after- treatment of 6 patients, but found no significant result. Conclusions: Multiple neural networks dysfunction may play roles in BPS.Combined effects of rTMS and botulinum toxin therapy in benign essential blepharospasm
Objective: To determine whether repetitive transcranial magnetic stimulation (rTMS) of anterior cingulate cortex (ACC) when added to botulinum toxin (BoNT) therapy improves benign essential blepharospasm…Clinical profile of patients with blepharospasm
Objective: To present the clinical profile of 61 patients with blepharospasm who were treated with onabotulinum toxin injections. Background: Blepharospasm is a focal dystonia that…Abnormal DaTscan in a case of Anoxic brain injury
Objective: To study the utility of DaTscan in anoxic brain injury. Background: Parkinsonism is a clinical syndrome seen in Parkinson Disease (PD) which includes tremors,…Mutational analysis of GNAL gene in isolated dystonia patients from Spain
Objective: To study the frequency and spectrum of GNAL genetic variations in a large population of isolated dystonia (DT) patients from Spain. Background: GNAL encodes…Sensory tricks in primary blepharospasm and cervical dystonia
Objective: To study the frequency, types, phenomenology and effectiveness of sensory tricks in primary blepharospasm and cervical dystonia patients. Background: Sensory tricks or geste antagoniste…Categories of psychogenic movement disorders to functional blepharospasm
Objective: 1) To investigate if the categories of psychogenic dystonia (PD) proposed by Gupta and Lang could be applied to psychogenic blepharospasm (PB); 2) To…Altered inter-hemispheric functional coordination in primary blepharospasm
Objective: The present study aimed to examine the inter-hemispheric functional connectivity of the whole brain in patients with BSP during resting state. Background: Abnormalities in…Gaze evoked blepharospasm
Objective: Herein we present a patient with asymmetric blepharospasm (BLS) evoked by upward gaze. Background: Essential BLS is a focal presentation of dystonia. However, brain…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.