Depression and cognitive impairment in isolated focal-onset dystonia: prevalence and risk factors in a group of Romanian patients
Objective: To assess the prevalence of depression and cognitive impairment and their potential risk factors in a group of Romanian patients with isolated focal-onset dystonia…Microstructural Changes in Basal Ganglia and Cerebellar Networks in Patients with Idiopathic Blepharospasm
Objective: In this study, we aimed to assess structural connectivity alterations in the basal ganglia, thalamus and cerebellum in patients with idiopathic blepharospasm (BS) compared…A case of severe blepharospasm after psoralen and ultraviolet A treatment
Objective: Report a case of blepharospasm secondary to PUVA therapy Background: Blepharospasm is a focal dystonia that can present as spasms of the eyelids, involuntary…Bilateral Globus Pallidum interna stimulation for Blepharospasm
Objective: Deep brain stimulation (DBS) of the Globus Pallidus Interna (GPi) is performed for treatment of medically intractable dystonia, including primary generalized dystonia, myoclonic dystonia,…The ultrasound image of the nuclei raphes changes in the group of depressed patients with cervical dystonia and blepharospasm
Objective: The ultrasound image of the nuclei raphes changes in the group of depressed patients with cervical dystonia and blepharospasm Background: Nuclei raphe - a…Non-motor symptoms and alteration of brain networks in patients with blepharospasm and hemifacial spasm
Objective: To investigate the differences of non-motor symptoms and the alteration of intrinsic brain networks in patients with blepharospasm and hemifacial spam. Background: Blepharospasm (BSP)…Postural Stability in Blepharospasm and the Effects of Botulinum Toxin Therapy
Objective: To determine (1) how blepharospasm effects postural stability and (2) to evaluate the efficacy of botulinum toxin therapy (BoNT-A) on static balance in patients…Cost-utility analysis of flexible interval incobotulinumtoxinA versus onabotulinumtoxinA in the management of blepharospasm and cervical dystonia in Ontario, Canada.
Objective: To carry out a cost-utility analysis for IncoBTX administered with flexible treatment intervals compared to OnaBTX in the management of BL and CD from…Multiple Neural Networks dysfunction in Primary Blepharospasm: An Independent Components Analysis Study
Objective: This study aimed to explore altered functional brain connectivity and the possible correlations of these networks with clinical variables in BPS. Background: Primary blepharospasm (BPS) is a focal dystonia characterized by involuntary blinking and eyelid spasms. The pathophysiology of BPS remains unclear. Methods: Twenty-five patients with BPS and 25 age-and gender-matched healthy controls received resting-state fMRI scan. Group ICA was performed with the GIFT toolbox. Results: (1) There were no significant differences in the demographic variables between two groups besides the HAMA scores [table 1]. (2) Comparing with healthy control group, BPS patients exhibited different resting-state connections within sensory-motor network (SMN), right frontoparietal network (rFPN) and salience network (SN) [figure 1, figure 2]. BPS patients exhibited decreased connectivity within SMN that involved regions of the bilateral primary sensorimotor cortex, supplementary motor area, right superior frontal gyrus (BA 6), bilateral precuneus and left superior parietal cortex [table 2]. Within rFPN, decreased connections were observed in the middle frontal gyrus, DLPFC and inferior frontal gyrus [table 3]. Regarding salience network, increased connectivity was observed in the left superior frontal gyrus and middle frontal gyrus (including the DLPFC) [table 4]. We found positive correlation between the left superior frontal gyrus and HAMA scores, but this result was not significant. (3) Among the BPS patients, 12 performed sensory tricks positive (ST+), 9 perform sensory tricks negative (ST-). ST+ as compared to ST- patients exhibited significant higher connectivity in right premotor cortex within SMN [figure 3, table 5]. The results also showed a significant negative correlation between the right superior frontal gyrus and disease duration (Pearson's correlation r = -0.414, p = 0.038)[figure 4]. (4) We compared the SMN connectivity maps from pre- and after- treatment of 6 patients, but found no significant result. Conclusions: Multiple neural networks dysfunction may play roles in BPS.Combined effects of rTMS and botulinum toxin therapy in benign essential blepharospasm
Objective: To determine whether repetitive transcranial magnetic stimulation (rTMS) of anterior cingulate cortex (ACC) when added to botulinum toxin (BoNT) therapy improves benign essential blepharospasm…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.