Mitochondrial phenotype related to the A30P alpha-synuclein mutation as a patient-derived cellular model of Parkinson’s disease
Objective: Our study aims to perform detailed phenotyping of the A30P alpha-synuclein familial case of PD, allowing to identify underlying mechanisms of the disease that…The Association between Infections and Parkinson Disease: A Systematic Review and Meta-analysis
Objective: Our study aimed to recapitulate and summarize the findings from the literature to provide an overview on the correlation between infection and PD. Background:…Cerebrospinal fluid biomarkers in Huntington’s disease – a longitudinal study
Objective: To validate the role of NFL as a marker of disease progression and to discover new biomarkers in HD. Background: Neurofilament light chain (NFL)…Mutant DNAJC13 modulates accumulation and toxicity of alpha-synuclein through altered endosomal trafficking in cell and fly models of Parkinson’s disease
Objective: The aim of this study is to investigate the effect of DNAJC13 mutation on the vesicle transport, α-synuclein (αSYN) distribution/catabolism, and neurodegeneration using a…Mesencephalic astrocyte-derived neurotrophic factor alleviated 6-OHDA-induced cell damage via ROS-AMPK/mTOR mediated autophagic inhibition
Objective: In this study, we investigated the role of autophagy system in MANF-mediated neuroprotection against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity. Background: Autophagy and apoptosis are commonly involved…Assessment of neurodegeneration and spreading of α-synuclein pathology induced by structurally defined α-synuclein assemblies in wild-type mice
Objective: The aim of this study was to investigate, in wild-type mice, the spreading and neurodegeneration induced by intracerebral injection of structurally well-defined α-synuclein assemblies…Expression of late cell cycle markers in Parkinson Disease and Lewy Body Dementia
Objective: The objective of this study is to determine the expression of late cell cycle markers in Parkinson Disease (PD) and Lewy Body Dementia (LBD) Background:…Lewy body extracts from Parkinson’s disease brains as models for high-throughput screens of neurotoxicity and α-synuclein spreading from cell-to-cell
Objective: To validate the effect of Lewy body extracts from Parkinson's disease (PD) brains in high-throughput screens of neurotoxicity and the α-synuclein (α-syn) spreading from…Piper longum L. alkaloids inhibit lipopolysaccharide-stimulated microglial activation and protect nigral dopaminergic neurons
Objective: The ethanol-extracted alkaloids from the dry seeds of Piper longum L. (PLL) (family Piperaceae) PLA contain numerous compounds. We evaluate the potential of PLA…Characteristics of the interaction between different toxic aggregated species of alpha-synuclein and cell membrane
Objective: To determine (1) the interaction rate of each toxic aggregated species of alpha-synuclein (α-Syn) with cell membrane compare to the monomeric form, (2) the…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.