Development of a time-to-event endpoint for use in premanifest Huntington’s disease (HD) clinical trials
Objective: To develop and evaluate a time-to-event endpoint to measure disease progression in individuals with premanifest HD. Background: HD is typically diagnosed between the ages…Implementation of an online, interactive curriculum in movement disorders at nine neurology residency programs
Objective: Determine knowledge growth and resident satisfaction with an online curriculum in movement disorders across multiple programs. Background: Exposure to movement disorders in residency is…How Well Does the Composite Unified Huntington’s Disease Rating Scale (cUHDRS) Reflect Disease Progression in Huntington’s disease (HD)?
Objective: To examine the usefulness of the cUHDRS in reflecting disease progression in a well-characterized group of mild to moderate HD subjects followed at one…Sleep and Polysomnographic Abnormalities in Indian Patients with Huntington’s Disease
Objective: To study the sleep abnormalities in patients with HD by usingquestionnaire and Video Polysomnography (VPSG) and correlate with the eye movement abnormalities. Background: About 87.8% of the patients report some sleep disturbance…Speech is a sensitive marker in premanifest Huntington’s disease: exploring acoustic, cognitive and fine motor performance
Objective: To explore the utility of objective analysis of speech as a quantifiable clinical biomarker in premanifest HD. Background: The autosomal dominant inheritance of Huntington’s…Huntington’s Disease in Israel – 20 years of follow up from Maccabi Healthcare Services
Objective: To describe Huntington’s Disease (HD) epidemiology in Israel and depict comorbidities and longitudinal healthcare resources utilization. Background: HD is a rare, inherited neurodegenerative disorder,…Remote and frequent assessment of Huntington’s disease in clinical trials: Strategies for assessing and accounting for the practice effect
Objective: To assess the impact of task repetition on performance in digital assessments on Huntington’s disease (HD) and establish the number of practice test iterations…HD Constellation: A novel patient-centred approach to enriching clinical datasets by combining medical record chart review and Enroll-HD
Objective: HD Constellation aims to create a dataset providing a longitudinal view of the Huntington’s disease (HD) course, based on physician-provided medical records in the…Biological and Clinical Manifestations of Huntington’s disease in Gene Carriers Very Far from Predicted Onset: The Young Adult Study
Objective: To perform a deep phenotyping of a Huntington’s Disease (HD) cohort further from onset than previously studied to establish when disease related markers first…Longitudinal Utility of the Montreal Cognitive Assessment and Mini Mental State Exam in Huntington’s disease (HD)
Objective: Neuropsychological assessments are useful tools for examining and tracking cognitive impairment in individuals with neurological disorders; however, a full neuropsychological battery is not realistic…
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