A pilot study of plasma ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) as a potential blood-based biomarker in Parkinson’s disease
Objective: To determine plasma levels of UCH-L1 in patients with PD, and to investigate the association with both genetic (leucine-rich repeat kinase 2, LRRK2 and…Clinical differences between Parkinson’s disease motor phenotypes. Results from the COPPADIS Study Cohort
Objective: To describe the prevalence of different motor phenotypes in a large cohort of Parkinson´s disease (PD) patients and to analyze their clinical features in…Effect of dual task as rehabilitation therapy in Parkinson’s disease in the UPDRS III
Objective: To determine the effect of the dual task used as Rehabilitation therapy in the UPDRS III of patients with Parkinson's disease. Background: Parkinson's disease…The impact of APOε4 polymorphisms and mutations in the GBA gene on the clinical features of Dementia with Lewy Bodies among Ashkenazi Jews
Objective: We aimed to explore the frequency and clinical impact of APOε4 polymorphisms in a cohort of Ashkenazi Jewish (AJ) patients with Dementia with Lewy…Effect of Glucocerebrosidase enzymatic activity on neural activation during a cognitive task in Parkinson’s disease patients
Objective: To explore the potential correlation of blood Glucocerebrosidase (GCase) enzymatic activity with fMRI brain activity during Wisconsin Card Sorting Task (WCST), while assessing cognitive…Performance of Parkinson´s disease cognitive scale rating scale (PD-CRS) after subthalamic nucleus deep brain stimulation. Comparison with Mattis Dementia Rating Scale (MDRS) and Mini-Mental State Examination (MMSE)
Objective: To study the performance of PD-CRS before and after STN-DBS and compare their results with other recognized cognitive scales. Background: Deep brain stimulation of…Brain Mechanisms of Associative Memory Deficits in Parkinson’s Disease without Dementia
Objective: Characterization of neural mechanisms of associative memory deficits in Parkinson’s disease (PD) without dementia (PD-non-Dementia). Background: The early presence of memory deficits in PD…PTRHD1 loss-of-function mutation in an African family with parkinsonism and intellectual disability
Objective: To investigate the clinical features and identify the disease-causing gene in a black South African family affected by juvenile-onset parkinsonism and intellectual disability. Background:…Levodopa and subthalamic stimulation do not have the same effect on subjective cost for distal and axial efforts in Parkinson’s disease
Objective: To compare the effects of levodopa and subthalamic nucleus stimulation (STN-DBS) on decision-making tasks for distal (hand) and axial (speech) efforts in Parkinson’s disease…It takes two to tango but following may be more beneficial for rehabilitating people with mild-moderate Parkinson’s
Objective: This study determined the efficacy of internally guided (leading) versus externally guided (following) in adapted tango versus a contact-matched control group (wellness education) for…
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