Session Information
Date: Wednesday, September 25, 2019
Session Title: Cognition and Cognitive Disorders
Session Time: 1:15pm-2:45pm
Location: Agora 3 East, Level 3
Objective: To identify modifiable vascular risk factors (VRFs) associated with cognitive decline in early PD.
Background: The importance of the early identification of modifiable risk factors associated with Mild Cognitive Impairment in Parkinson’s Disease is growing.
Method: PD patients of the PaCoS cohort who underwent a baseline and follow-up neuropsychological evaluations were enrolled in the study. PD-MCI and PDD were diagnosed according to the MDS criteria. Baseline brain MRI was used to calculate the white matter lesions (WMLs) burden using a visual scale. Laboratory data, presence of hypertension, diabetes and use of anti-hypertensive drugs were collected and the Framingham cardiovascular disease Risk Score (FRS) was calculated. VRFs predicting MCI and PDD were evaluated using Cox proportional hazard regression model.
Results: Out of 139 enrolled PD patients, 84 were classified as normal cognition (NC), 55 (39.6%) as MCI at baseline. At follow-up 28 (33.3%) PD-NC developed MCI and 4 (4.8%) PDD. Out of 55 PD-MCI patients at baseline, 14 (25.4%) converted to PDD at follow-up. Among PD-NC the presence of a higher systolic blood pressure (>135 mmHg) and use of anti-hypertensive were the stronger predictors of MCI at follow-up (adjHR 5.12; 95%CI 1.48-17.76; p-value 0.01 and adjHR 7.13; 95%CI 2.11-24.13: p-value 0.002 respectively). For PDD the risk was associated with MCI at baseline (adj HR 11.4; 95%CI 2.39-54.64; p-value 0.002), and a higher WML burden (adj HR 4.50 1.20-16.8 p-value 0.02).
Conclusion: In our sample the presence of hypertension at baseline represented the most important modifiable risk factors increasing of about 6 times the risk of MCI.
To cite this abstract in AMA style:
A. Luca, R. Monastero, G. Donzuso, R. Baschi, C. Cicero, C. Terravecchia, A. Salerno, M. Zuccarello, M. Davì, V. Restivo, G. Mostile, M. Zappia, A. Nicoletti. Vascular risk factors, WMLs and the risk of cognitive impairment in Parkinson disease: A longitudinal study from the Parkinson’s Disease Cognitive Impairment Study (PaCoS) cohort [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/vascular-risk-factors-wmls-and-the-risk-of-cognitive-impairment-in-parkinson-disease-a-longitudinal-study-from-the-parkinsons-disease-cognitive-impairment-study-pacos-cohort/. Accessed December 10, 2024.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/vascular-risk-factors-wmls-and-the-risk-of-cognitive-impairment-in-parkinson-disease-a-longitudinal-study-from-the-parkinsons-disease-cognitive-impairment-study-pacos-cohort/