A prospective study of Parkinson’s disease progression towards dementia – dynamics and defining motor features
Objective: Our goal was to investigate the rate of progression to dementia (PDD) in our cohort of Parkinson’s disease (PD) patients and to explore how…Morbidity and mortality from neurodegenerative patients hospitalized with COVID-19 in the Chicagoland area
Objective: To assess morbidity and mortality of acute COVID-19 infection in hospitalized patients with neurodegenerative diseases and compare with age-matched controls. Background: Outcomes from COVID-19…Genetic factors associated with dementia in Parkinson’s disease in the Parkinson’s Incidence Cohorts Collaboration (PICC)
Objective: To evaluate the effect of genetic variants in β-glucocerebrosidase (GBA), apolipoprotein E (APOE), microtubule-associated protein tau (MAPT), and α-synuclein (SNCA) loci on the risk…Methods for addressing missing covariate data in left truncated samples with application to Parkinson’s disease research
Objective: To investigate the impact of left truncation on commonly used missing data approaches and explore this impact in a Parkinson’s disease dementia study. Background:…CSF MicroRNA Analysis Reveals Angiogenesis And Autophagy Defects In Parkinson’s DiseasePatients
Objective: We investigated the effects of discoidin domain receptor (DDR)-1 inhibition on CSF miRNAs in Parkinson’s disease patients. Background: MicroRNAs (miRNAs) are post-transcriptional regulators of…Therapy to Reduce dementia risk In Parkinson’s disease (TRIP): Proof-of-concept trial
Objective: The TRIP proof-of-concept study examines functioning of the hippocampal DG/CA3 subregion as a biomarker and therapeutic target for memory impairment in Parkinson’s Disease (PD).…Distinct memory networks in Parkinson’s disease (PD) and Alzheimer’s disease (AD): Effects of APOE
Objective: As part of the Ontario Neurodegenerative Disease Research Initiative, we investigated group differences in functional connectivity within two distinct memory networks: posterior medial network…Exploring the Potential Anti-dementia Roles of Selected Herbal Anti-inflammatory Remedies in Parkinson’s Disease: Hopes and Challenges
Objective: To evaluate anti-dementia properties of the selected herbal anti-inflammatory remedies Background: Parkinson’s disease (PD) is the most common age-related neurodegenerative disease after Alzheimer’s disease.…The Neuropsychiatric Inventory:Assessment Of Neuropsychiatric Symptoms In Parkinson’s Disease
Objective: We investigated the correlation of Neuropsychiatric Inventory(NPI) test score with progression of PD. Background: PD has characteristic motor symptoms and non-motor symptoms including psychiatric…Parkinsonism in a patient with limbic-predominant age-related TDP-43 encephalopathy (LATE) syndrome
Objective: To illustrate a case of parkinsonism in a patient with LATE syndrome. Background: LATE syndrome is an emerging subclassification of TDP-43 proteinopathy. Symptoms include…
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