Biomarkers of rapid progression of cognitive decline in Parkinson’s disease
Objective: We aimed to explore cross-sectional grey-matter volume (GMV) and CSF biomarkers differences in PD patients exhibiting a rapid progression of cognitive decline compared to…Motor and non-motor correlates of APOE-ε4 mediated cerebrospinal fluid concentrations of biomarkers of amyloidogenesis and neurodegeneration in dementia with Lewy bodies compared with Alzheimer’s dementia and healthy controls
Objective: To study associations of cerebrospinal fluid biomarkers of amyloidogenesis and neurodegeneration with motor and non-motor aspects of daily experiences in dementia with Lewy bodies…Alzheimer’s Disease Genetic Risk Variants Predict Cognitive Decline in Parkinson’s Disease
Objective: To evaluate the effect of genetic variants implicated in Alzheimer’s disease (AD) risk on cognitive decline in Parkinson’s disease (PD). Background: People with PD…Dielectric Properties of Blood Plasma Predict Cognitive Impairment in an Amyloid-Beta-Induced Rat Model of Alzheimer’s Dementia
Objective: This study presents a novel method of predicting the behavioral pattern in male Sprague-Dawley rats with impaired learning and memory, based on the measurement…Evaluation of the Loneliness among the Caregivers of Parkinson Disease Dementia
Objective: This study examined loneliness among caregivers of individuals with Parkinson’s disease dementia(PDD). Background: Caregivers of people with PDD have loneliness and depression. Methods: The…SYN120 (a Dual 5-HT6/5-HT2A Antagonist) Study to Evaluate Safety, Tolerability and Efficacy in Parkinson’s Disease Dementia (SYNAPSE): Phase 2a Study Results
Objective: To evaluate the safety and preliminary efficacy of SYN120 in patients with Parkinson's disease dementia (PDD). Background: SYN120 is an antagonist of serotonin receptors…Interaction between MAPT H1 and APOE4 in early Parkinson’s Disease
Objective: To define if the high risk MAPT allele of rs393152 (H1 haplotype) is associated with differences in brain structure, clinical presentation, progression or cognitive…Impact of SYN120 (a Dual 5-HT6/5-HT2A antagonist) on psychiatric symptoms in patients with Parkinson’s disease dementia: Results from a Phase 2a Study
Objective: To assess the psychiatric effects of SYN120 in patients with Parkinson's disease dementia (PDD). Background: SYN120 is a dual antagonist of serotonin (5-HT6 and…Balance and gait analysis of GBA mutation carriers with Parkinson’s disease (PD)
Objective: To use quantitative inertial sensor-based postural sway and gait analysis to determine potential differences in the pattern of balance and gait impairment in the…Longitudinal observational study on late onset Parkinson’s disease over a decade
Objective: 1. To analyse the outcome of Late onset Parkinson’s disease over ten year period. 2. To look for any relationship between Initial cognition to…
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