Motor and non-motor correlates of APOE-ε4 mediated cerebrospinal fluid concentrations of biomarkers of amyloidogenesis and neurodegeneration in dementia with Lewy bodies compared with Alzheimer’s dementia and healthy controls
Objective: To study associations of cerebrospinal fluid biomarkers of amyloidogenesis and neurodegeneration with motor and non-motor aspects of daily experiences in dementia with Lewy bodies…Alzheimer’s Disease Genetic Risk Variants Predict Cognitive Decline in Parkinson’s Disease
Objective: To evaluate the effect of genetic variants implicated in Alzheimer’s disease (AD) risk on cognitive decline in Parkinson’s disease (PD). Background: People with PD…Dielectric Properties of Blood Plasma Predict Cognitive Impairment in an Amyloid-Beta-Induced Rat Model of Alzheimer’s Dementia
Objective: This study presents a novel method of predicting the behavioral pattern in male Sprague-Dawley rats with impaired learning and memory, based on the measurement…Evaluation of the Loneliness among the Caregivers of Parkinson Disease Dementia
Objective: This study examined loneliness among caregivers of individuals with Parkinson’s disease dementia(PDD). Background: Caregivers of people with PDD have loneliness and depression. Methods: The…SYN120 (a Dual 5-HT6/5-HT2A Antagonist) Study to Evaluate Safety, Tolerability and Efficacy in Parkinson’s Disease Dementia (SYNAPSE): Phase 2a Study Results
Objective: To evaluate the safety and preliminary efficacy of SYN120 in patients with Parkinson's disease dementia (PDD). Background: SYN120 is an antagonist of serotonin receptors…Interaction between MAPT H1 and APOE4 in early Parkinson’s Disease
Objective: To define if the high risk MAPT allele of rs393152 (H1 haplotype) is associated with differences in brain structure, clinical presentation, progression or cognitive…Impact of SYN120 (a Dual 5-HT6/5-HT2A antagonist) on psychiatric symptoms in patients with Parkinson’s disease dementia: Results from a Phase 2a Study
Objective: To assess the psychiatric effects of SYN120 in patients with Parkinson's disease dementia (PDD). Background: SYN120 is a dual antagonist of serotonin (5-HT6 and…Balance and gait analysis of GBA mutation carriers with Parkinson’s disease (PD)
Objective: To use quantitative inertial sensor-based postural sway and gait analysis to determine potential differences in the pattern of balance and gait impairment in the…Longitudinal observational study on late onset Parkinson’s disease over a decade
Objective: 1. To analyse the outcome of Late onset Parkinson’s disease over ten year period. 2. To look for any relationship between Initial cognition to…Association of GBA polymorphisms and mutations with dementia in Parkinson disease: A 7-year study of three population-based incident cohorts
Objective: To study the effect of GBA variants on dementia in three deeply phenotyped population-based prospective cohorts of patients with incident Parkinson disease. Background: Dementia…
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