Speech prosody impairment predicts cognitive decline in Parkinson’s disease
Objective: We assessed whether baseline speech prosodic parameters, alone or in combination with other predominantly non-dopaminergic symptoms may predict global cognitive decline as measured by…Safety of nelotanserin in a randomized placebo-controlled phase 2 study
Objective: To explore the safety of nelotanserin in a phase 2 study in patients with nelotanserin. Background: Nelotanserin is a highly selective and poent inverse…How many and which kind of Parkinson’s disease patients need deep brain stimulation surgery? An evaluation based on clinical observation of patients with disease history of 15th year or more
Objective: To grasp real demand of deep brain stimulation (DBS) surgery in a substantial Parkinson's disease (PD) population. Background: DBS surgery has become frequently performed…Genetic risk factors of dementia and psychosis in Parkinson’s disease
Objective: We investigated the impacts of apolipoprotein E (APOE) genotype and glucocerebrosidase gene (GBA) heterozygote mutations on dementia or psychosis in Parkinson's disease (PD). Background:…Olfactory performance and resting state functional connectivity in non-demented drug naïve patients with Parkinson’s disease
Objective: We investigated the pattern of resting state functional connectivity in patients with PD according to olfactory performance to elucidate olfactory-dependent cortical-subcortical functional networks. Background:…
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