Ecopipam does not adversely affect Metabolic Parameters in Pediatric Subjects with Tourette Syndrome: Results from a Phase 2b with 12-month Open Label Extension Study
Objective: Determine if ecopipam is associated with the emergence of clinical features suggestive of metabolic syndrome in pediatric subjects with Tourette Syndrome (TS) Background: Dopamine-2…Antipsychotic Prescriptions Among Nursing Home Residents with Parkinson’s Disease in the End-of-Life Period
Objective: To determine whether antipsychotic prescriptions differ between community-dwelling and nursing home residents with PD in the last 6 months of life. Background: Most antipsychotics…Examination of how DaTscan Impacts Diagnosis in Parkinsonian Patients with and without Dopamine Receptor Blocking Agent Exposure
Objective: To determine whether Dopamine transporter imaging impacts diagnosis in parkinsonian patients Background: Dopamine transporter imaging (DaTscan) is a diagnostic tool used to assess loss…Effect of Ecopipam, a Selective Dopamine-1 Receptor Antagonist, on Tic Characteristics as Assessed by the YGTSS: Results from a Phase IIb Randomized, Double-blind, Placebo-controlled Clinical Trial in Tourette Syndrome
Objective: Assess the effect of ecopipam treatment on motor and phonic/vocal tic characteristics: number, frequency, intensity, complexity, and interference comprising the Yale Global Tic Severity…Long-term safety and durability of effect of ecopipam in pediatric patients with Tourette Syndrome: Results of a 12-month open-label extension (OLE) study
Objective: Assess the safety and durability of effect of long-term treatment with ecopipam in pediatric patients with Tourette syndrome (TS). Background: TS is a childhood-onset…Efficacy of levodopa/carbidopa/entacapone replacement of levodopa/dopa decarboxylase inhibitors in treatment of Chinese Parkinson’s disease patients with wearing-off: a multicenter, randomized controlled, open label study
Objective: This study aimed to investigate the efficacy and safety comparison between LCE and Pramexol in Chinese PD patients with the wearing-off phenomenon. Background: Wearing…Tardive dystonia manifesting in lid-opening apraxia, oromandibular dystonia, and laterocollis after long-term sulpiride use
Objective: We describe a patient who developed tardive dystonia after sulpiride treatment for over two decades. Few cases have been reported[1-3], thus we offer an…Hemichorea syndrome secondary to diabetic striatopathy with contralateral drug-induced parkinsonism: a different threshold for drug induced movement disorders?
Objective: Localized structural damages could impair the threshold of activation and/or inhibition of the nigrostriatal pathway with a mirrored effect on the healthy and pathological…Effect of Best Practice Advisory on the administration of contraindicated medications to hospitalized patients with Parkinson’s disease and related disorders
Objective: To determine if a best practice advisory (BPA) reduced the orders and administration of contraindicated dopamine blocking agents (DBA) to hospitalized patients with Parkinson’s…Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study of Ecopipam in Children and Adolescents with Tourette Syndrome
Objective: Evaluate the efficacy and safety of ecopipam in children and adolescents with Tourette’s Syndrome (TS). Background: Ecopipam, a first-in-class selective dopamine-1 (D1) receptor antagonist…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.