Quantification of Striatal and Extrastriatal Dopamine Transporters with [18F]PR04.MZ and [18F] PI- 2620 PET in Patients with Progressive Supranuclear Palsy.
Objective: We aim to evaluate the differences in striatal subregional dopamine transporter loss between Parkinson disease (PD) and progressive supranuclear palsy (PSP) of any stage…Preclinical characterization of UCB0022, an oral, brain penetrant, selective, clinical-stage positive allosteric modulator of the dopamine 1 receptor (D1 PAM)
Objective: To characterize the in vitro and in vivo pharmacologic profile of UCB0022 Background: Parkinson’s disease (PD) is a progressive neurodegenerative disease with reductions in…PP1α negatively regulates D2 receptor mediated cadmium induced motor dysfunctions: protective potential of Quercetin.
Objective: The present study has been focused to identify the molecular targets that involved in Cadmium-induced motor dysfunctions. At the same time, we also focused…The study of genetic factors in motor levodopa-induced complications development in Russian patients with Parkinson’s disease
Objective: This study is aimed to explore the relationship between the single nucleotide polymorphisms (SNPs) in dopamine metabolism genes and development of motor side effects…Clinical and genetic analysis of psychosis in Parkinson’s disease
Objective: This study aimed to examine the association of seven selected polymorphisms of DRD2, ANKK1, COMT and DAT genes with Parkinson’s disease psychosis (PDP) onset.…Behavioral effects of stimulated dopamine release and D2-like receptor displacement in Parkinson’s patients with impulse control disorder
Objective: To evaluate behavioral effects of stimulated dopamine (DA) release in Parkinson’s disease (PD) by assessing D2/3 receptor (DA-R) displacement on PET imaging Background: Previous…Role of S100B in the Pathogenesis of Parkinson’s Disease
Objective: This review aims to analyze studies on the implication of S100B in Parkinson's Disease (PD) and shed light on Pentamidine as a novel treatment in…Childhood-Onset Hemidystonia: A Transportophaty related to SLC6A3 missense mutation
Objective: To present the case of a childhood-onset hemidystonia carrying a homozygous SLC6A3 missense mutation. Background: Dystonia is a movement disorder characterized by sustained or…Using a Dopamine Genetic Risk Score to Predict Impulse Control Behaviours for Parkinson’s Disease Patients
Objective: The current study aimed to utilise a dopamine genetic risk score and objective laboratory-based behavioural measures of impulse control to identify Parkinson’s patients most…Graph theory analysis of dopamine D2 receptor network in Parkinson’s disease patients
Objective: The aim of this study was to explore a novel method of analyzing positron emission tomography (PET) data using graph theory analysis. To this…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.