Co-administration of levodopa and zonisamide reduces the serotonin transporter expression in a rat model of Parkinson’s disease
Objective: To investigate the change of striatal serotonergic system according to the administration of levodopa and zonisamide (ZNS) on the striatal serotonergic system, we analyzed the…Assessing the validity and reliability of MANAGE-PD tool to identify patients with Parkinson’s disease inadequately controlled on oral medications – Results from an international survey of general neurologists and movement disorder specialists
Objective: To evaluate the validity and reliability of MANAGE-PD tool. Background: Timely identification of advancing symptoms in patients with Parkinson’s Disease (PD), thereby improving opportunities…Risk Thresholds of Levodopa Dose for Dyskinesia in Chinese Patients with Parkinson’s Disease: A Pilot Study
Objective: The objective of this study was to investigate the thresholds of levodopa dose to reduce the risk for dyskinesia in a Chinese PD population.…The Role of Dysfunctional BDNF in Remodeling the Parkinsonian Striatum Following Dopamine Neuron Grafting in CRISPR rs6265 Rats
Objective: To evaluate the impact of the rs6265 Bdnf single nucleotide polymorphism (SNP) on function & synaptic integration of primary dopamine (DA) neuron grafts in…Levodopa Induced dyskinesia in patients with Parkinson’s disease and polymorphisms gene DRD3 dopamine receptor
Objective: The aim of this study was to investigate the association between two DRD3 gene single-nucleotide polymorphisms (SNPs) and the development of LID in patients…NS-PARK cohort: a nationwide real life longitudinal cohort of PD patients
Objective: To describe the Parkinson disease (PD) population followed by the 25 expert centers for PD in France. Background: NS-PARK is the clinical research network…Advanced autonomous motor state detection from wrist-worn sensor in persons with PD
Objective: To explore the advancement of precision and granularity of motor state detection in persons with PD (PwP) from wrist-worn sensor data. Background: The motor…OPICAPONE: REAL WORLD EVIDENCE IN TOLEDO´S MOVEMENT DISORDERS UNIT
Objective: We present a prospective observational-real life study about the use in Movement Disorders Unit´s patients, since its commercialization in Spain (June 2017). Background: The…Motor and non-motor symptoms burden, autonomy, quality of life and principal caregiver status is worse in patients with 5-2-1 positive criteria: a simple screening tool for identifying PD patients who need an optimization of Parkinson´s treatment.
Objective: To compare quality of life (QoL), non-motor symptoms (NMS) burden, autonomy for activities of daily living (ADL) and patient´s principal caregiver status in PD…Predicting the impact of Parkinson’s disease on a patient’s gait: the potential of innovative approaches based on instrumented clinical tests
Objective: To investigate the potential to predict the impact of the patient’s symptomatology on his ability to walk. Specifically, we (1) formed clusters of performance…
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