Impact of Multi-day Wearable Monitoring on Neurologists’ Assessment of Motor Fluctuations and Treatment Strategies in Parkinson’s Disease: A Real-World Study
Objective: To assess the impact of wearable-device objective metrics on neurologists’ perception and therapeutic decisions in a real-world cohort of patients with Parkinson’s disease (PD).…Progressive Lifelong Chorea with Spastic Paraparese and Cerebellar Ataxia Associated with Two Heterozygous Variants in the SYNE1 Gene: A Case Report
Objective: To report a case harboring two different heterozygousSYNE1 variants whose combined effect is suspected tounderlie a complex neurogenetic phenotype Background: SYNE1 encodes nesprin-1, one…Continuous Subcutaneous Foslevodopa/Foscarbidopa Infusion in Advanced Parkinson’s Disease: Results from a Prospective Real-world Study
Objective: To evaluate the effectiveness and tolerability of continuous subcutaneous foslevodopa/foscarbidopa (LDp/CDp) infusion in patients with advanced Parkinson’s disease (PD) in a real-world setting. Background: In…Prosaposin differentially modulates lipid metabolism of striatal and non-striatal dopamine D1 receptor-expressing neurons and regulates L-DOPA-induced dyskinesia
Objective: Chronic treatment of L-DOPA causes dyskinesia (LID) in PD patients. We aim to understand LID from a lipid-metabolism perspective and identify novel therapeutic targets.…Unmasking the Masquerader: Paroxysmal Kinesigenic Dyskinesia (PKD) Misdiagnosed as Epilepsy for Nearly a decade: Time to Act (Consecutive Cohort of 25 patients)
Objective: To characterize the clinical phenotype, diagnostic journey and one year treatment outcomes in paroxysmal kinesigenic dyskinesia (PKD) at a tertiary movement disorder centre in…A Novel Dopaminergic Modulator (NDM-101) as an Adjunct to Levodopa: Enhancing Motor Control Without Worsening Dyskinesia in Parkinson’s Disease
Objective: To evaluate the efficacy and safety of NDM-101 as an adjunct to levodopa in reducing OFF-time, improving motor function, and maintaining quality of life…Plasma neurofilament light chain in early Parkinson’ s disease predicts motor complications: A Prospective Cohort Study
Objective: The current study aimed to identify risk plasma biomarkers in early-stage PD for future motor complications through a longitudinal Chinese PD cohort, which ultimately…Optimizing deep brain stimulation programming settings for patients with stimulation-induced dyskinesias in Parkinson’s disease
Objective: To assess the impact of Deep Brain Stimulation (DBS) parameters on stimulation-induced dyskinesias (SID) in patients with Parkison’s Disease (PD). Background: SID resemble levodopa-induced…Association Between Pesticide Exposure and Clinical Outcomes in Parkinson’s Disease: A Propensity-Matched Cohort Study
Objective: To evaluate the clinical outcomes associated with pesticide exposure in Parkinson’s disease (PD) participants in the Canadian Open Parkinson Network (COPN)(1). Background: Pesticide exposure…Foscarbidopa/Foslevodopa Therapy Improves Continuous Duration of Good ON Time and Correlated With Quality of Life in People With Parkinson’s Disease
Objective: To assess the impact of foscarbidopa/foslevodopa (CDp/LDp) continuous subcutaneous infusion (CSCI) on longest consecutive duration of Good and Best ON time and association of…
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