Multimodal Imaging in Cervical Dystonia with Botulinum Toxin Treatment: A Pilot 5.0T MRI and 99mTc-MIBI SPECT/CT Study
Objective: To comprehensively investigate structural, vascular, and metabolic alterations in cervical dystonia (CD) patients using ultra-high-field 5.0T magnetic resonance imaging (MRI) and 99mTc-MIBI SPECT/CT. Background:…Investigating Subthalamic Neuronal Activity in Parkinsonian Patients with Hemidystonia
Objective: In this study we aimed to investigate differences in the subthalamic nucleus (STN) activity in Parkinson’s disease (PD) patients who developed hemidystonia. Background: STN…STN Neuronal Activity Shows Complex and Patient-Dependent Differences in Akinetic-Rigid Parkinson’s Disease With and Without Dystonia
Objective: The aim of the current study is to distinguish and characterize subthalamic (STN) neuronal activity specifically related to dystonia in Parkinson’s disease (PD) patients.…Identification of a sporadic dystonia-related brain network using resting-state fMRI and machine learning
Objective: To identify and characterize sporadic dystonia-related network (SDRN) using resting-state fMRI (rs-fMRI) and machine learning. Background: Sporadic dystonia is a hyperkinetic movement disorder characterized by…Voxel-Based Morphometry Reveals Gray Matter Volume Reductions in Sporadic Dystonia
Objective: To investigate gray matter (GM) volume changes in sporadic dystonia (SD) using T1 MRI and voxel-based morphometry (VBM). Background: Dystonia is a hyperkinetic movement…Temporal Prediction and Multisensory Integration in Musician’s Dystonia
Objective: We aimed to determine whether temporal prediction and multisensory integration are altered in musician’s dystonia (MD) and whether task-specific visual, auditory, and audiovisual cues…Frequency-Dependent Disruption of Head-Trunk Control in Cervical Dystonia
Objective: To investigate postural control and head–trunk dynamics in isolated cervical dystonia (CD). Background: Postural control requires integration of visual, proprioceptive and vestibular inputs and…Pallidal Local Field Potentials modulation by Deep Brain Stimulation in Acquired Dystonia due to Kernicterus
Objective: To describe pallidal local field potential (LFP) recordings and their clinical correlates in a patient with acquired generalized dystonia secondary to kernicterus undergoing bilateral…Muscarinic receptor antagonism beyond M4 is required for efficacy in a preclinical model of dystonia and Parkinson’s disease
Objective: To inform the target activity profile of future movement disorder therapies, pre-clinical studies quantified the contribution of M4 receptor occupancy (M4RO) to reversal of…Cholinergic dysfunction associated to aberrant functional connectivity in Parkinson Disease-related dystonia
Objective: Assess presynaptic cholinergic integrity and associated functional connectivity differences in Parkinson disease (PD)-related dystonia. Background: Dystonia is observed in 30-60% of individuals with PD.…
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