Gait and stance events measured with smartwatches in patients with PD and ET
Objective: The goal of this study was to analyze differential gait patterns in patients with Parkinson's disease (PD) and essential tremor (ET). To this end,…Deep brain stimulation (DBS) of the caudal zona incerta improving gait stability and truncal tremor in a patient with essential tremor
Objective: We report on a 54 year old female with essential tremor (ET), bilateral deep brain stimulation (DBS) of the caudal zona incerta (CZi) who…The use of DaT-SPECT scanning in the differential diagnosis of Parkinsonism: Are guidelines being followed?
Objective: The aim of this study was to assess the adherence of a UK National Health Service (NHS) Parkinson’s disease service to National Institute for…Botulinum toxin in Essential Hand Tremor – A Randomized Double-Blind Placebo-Controlled study with Customized Injection Approach
Objective: To evaluate the safety and efficacy of incobotulinumtoxinA (IncoA) injection for treatment of Essential Tremor (ET). Background: In essential tremor and Parkinson's Disease tremor,…Can a novel digital pen system assist clinicians in the differential diagnosis of Parkinson’s disease?
Objective: Our aim was to assess the utility of a novel electronic pen system in the differential diagnosis of PD at the time of referral.…Quantitative characterisation of tremor in functional and organic tremor patients
Objective: To quantify tremor characteristics using inertial sensors in functional and organic tremor patients and to present the differences in tremor quantification between these two…Therapeutic exposures of CX-8998, a potent, selective and state dependent Cav3 channel antagonist in development for Essential Tremor and Parkinson’s disease Tremor in Cav3 driven neurological models
Objective: In this study, we utilized preclinical data to establish predicted human therapeutic exposures of the potent, selective and state-dependent Cav3 channel antagonist, CX-8998, currently…Local field potential changes during sleep in the PSA of patients with essential tremor
Objective: To investigate changes in local field potential (LFP) activity of the posterior subthalamic area (PSA) in patients with essential tremor (ET) during wakefulness and…Botulinum Toxin Injections in Upper Limb Tremor
Objective: To prospectively assess the outcome of patients receiving botulinum toxin (BoNT) injections for upper limb tremor refractory to oral medications. Background: Upper limb tremor…Proof-of-Principle Quantitative EEG Study of CX-8998, an Oral, Potent and Selective T-Type Calcium antagonist in development for symptomatic treatment of Essential Tremor and Parkinson’s disease Tremor
Objective: To study the pharmacodynamics (PD) of CX-8998, using pharmaco-electroencephalography (phEEG) and define plasma concentrations of CX-8998 which are pharmacologically active on objective CNS parameters.…
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