Therapeutic exposures of CX-8998, a potent, selective and state dependent Cav3 channel antagonist in development for Essential Tremor and Parkinson’s disease Tremor in Cav3 driven neurological models
Objective: In this study, we utilized preclinical data to establish predicted human therapeutic exposures of the potent, selective and state-dependent Cav3 channel antagonist, CX-8998, currently…Local field potential changes during sleep in the PSA of patients with essential tremor
Objective: To investigate changes in local field potential (LFP) activity of the posterior subthalamic area (PSA) in patients with essential tremor (ET) during wakefulness and…Botulinum Toxin Injections in Upper Limb Tremor
Objective: To prospectively assess the outcome of patients receiving botulinum toxin (BoNT) injections for upper limb tremor refractory to oral medications. Background: Upper limb tremor…Proof-of-Principle Quantitative EEG Study of CX-8998, an Oral, Potent and Selective T-Type Calcium antagonist in development for symptomatic treatment of Essential Tremor and Parkinson’s disease Tremor
Objective: To study the pharmacodynamics (PD) of CX-8998, using pharmaco-electroencephalography (phEEG) and define plasma concentrations of CX-8998 which are pharmacologically active on objective CNS parameters.…The utility of electrophysiological tests in the differentiation of upper limb tremor in young-onset patients
Objective: To explore the diagnostic utility of neurophysiologic tests in young-onset patients who present primarily with upper limb action tremor. Background: In young-onset patients, isolated…Magnetic resonance-guided focused ultrasound unilateral thalamotomy for the treatment of essential tremor: Outcomes and complications after 1 year of follow-up in 21 patients
Objective: To report the clinical experience in our center (CINAC-HM Puerta del Sur) in the treatment of essential tremor (ET) with Magnetic Resonance guided Focused…Patients with Essential Tremor Live Longer than their Relatives
Objective: The objective of this study is to compare the lifespans of patients with essential tremor (ET) with their relatives. Background: Essential tremor is a movement disorder…Clinical characteristics of Parkinson’s disease developed from essential tremor
Objective: The objective of this study is to compare the clinical characteristics of Parkinson’s disease developed from essential tremor (ET-PD) with the clinical characteristics of…Essential Tremor and Depression
Objective: To determine if depression and neuropsychiatric symptoms are more prevalent in patients with essential tremor (ET) compared with non-ET controls and if so, to establish…Non-motor symptoms in patients with Parkinson’s disease, essential tremor and both diseases – a group comparison
Objective: To evaluate non-motor symptoms in patients with essential tremor (ET), tremordominant Parkinson’s disease (PD) and those suffering from both diseases (ET-PD). Background: ET is…
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