- Eye tracking identifies biomarkers predicting Parkinson’s disease before motor symptom onsetObjective: To investigate eye movement changes as an early motor biomarker of Parkinson’s disease (PD) in patients with REM sleep behavior disorder (RBD). Background: RBD…
- Resolution Dependence of Machine Learning for Differential Diagnosis of Parkinsonian Eye MovementsObjective: To establish the extent to which high temporal resolution is required to differentiate between parkinsonian disease states from eye movements. Background: Previous studies have…
- Digital measurement of ocular microtremor in Parkinson’s Disease: Analytical and clinical validationObjective: This pilot study examined the analytical and clinical validation of OMT measurement via the iTremor ONE device in PwPD. Background: Ocular microtremor (OMT) is…
- Machine Learning Model using Eye Movements for the Differential Diagnosis of iPD and Atypical Parkinsonian SyndromesObjective: To develop a machine learning (ML) model to first between differentiate between healthy controls, idiopathic PD, Atypical Parkinsonian syndromes and then further subclassify as…
- Oculomotor Differences in PARK2 PD: a Study of Structured and Unstructured Eye Movements in an Irish Genetic CohortObjective: To identify and measure how eye movements differ between biallelic PARK2 carriers, carriers of a single PARK2 variant and non-carriers using structured and unstructured…
- Concomitant Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis Versus Motoneuron Phenotype of PSP in Ukrainian PatientObjective: To provide a description of a rare case of mixed progressive supranuclear palsy (PSP) and amyotrophic lateral sclerosis (ALS) in Ukrainian patient. Background: The…
- Multiscale entropy: a New Oculomotor Measure of PSP.Objective: The objective of this study was investigate whether multiscale entropy, a measure of complexity, when applied to the path of unconstrained eye movements could…
- Utilizing the 15-item modification of the PSPRS rating scale (mPSPRS-15) as the primary endpoint for future clinical trials in progressive supranuclear palsyObjective: To compare the properties of PSPRS-28, mPSPRS-15, and the rPSPRS-10 and assess their utility as a primary endpoint in PSP trials. Background: Progressive supranuclear…
- Peripheral neuropathy in Autosomal Recessive Spinocerebellar Ataxia due to ANO10 mutation – Expanding the phenotypic spectrumObjective: SCAR10/ Adult-onset autosomal recessive cerebellar ataxia is an exceptionally rare form of ataxia, caused by mutations in the ANO10 gene and the specific genotype–phenotypecorrelation…
- Oculomotor Abnormalities in Spinocerebellar Ataxia Type-12: A Functional Neuroimaging StudyObjective: This study aimed to investigate eye movements, specifically dysmetric saccades and cerebellar nystagmus, in Spinocerebellar Ataxia Type-12 (SCA12) using functional magnetic resonance imaging (fMRI)…
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