Basal Ganglia Circuits for Motor and Behavioral, Emotional Performances
Objective: The present study aimed to identify which neurons in the basal ganglia (BG) target dopaminergic or GABAergic neurons in SN pars compacta (SNc) or…Variability in the ideal target of GPi DBS for Parkinson’s disease requires advanced direct targeting for optimal results
Objective: Our findings have the potential to transform the clinical practice of surgeons who rely solely on indirect targeting, by raising awareness of the anatomic…The clinical benefit of pallidal stimulation in dystonia is related to the electrode position in the medio-lateral direction
Objective: To detect the relationship between the long-term clinical outcome of deep brain stimulation (DBS) in patients with dystonia and the electrode position in the…Effects of deep brain stimulation in the nucleus entopeduncularis on neuronal network activity after apomorphine-induced deficient sensorimotor gating in a rat model
Objective: Deficient sensorimotor gating induced by dopamine receptor agonists is used as an endophenotype for certain neuropsychiatric disorders, such as Tourette´s syndrome (TS), schizophrenia, and…Finding an optimal lead trajectory for a better stimulated volume in movement disorder therapy
Objective: Defining the best lead trajectory (Arc; Ring) with a computational 3D stereotactic model of the Globus Pallidus internus (GPi) and investigating the influence of…Results from a double-blind trial of pallidal DBS for Tourette’s syndrome: Are there any predictors of surgery outcome?
Objective: To explore whether individual patient characteristics can indicate response to treatment in a trial of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS)…DBS targeting: Validation of 3T MR image guided targeting using post-mortem 17T MR microscopy
Objective: This work helps validate the utility of direct targeting using 3T T1 inverted sequences with atlas application during planning for DBS electrode placement. We…When DBS can be of benefit in Huntington’s disease
Objective: To report on a patient with HD and disabling truncal dystonia who was treated with bilateral GPi DBS. Background: HD is an autosomal-dominant disorder…Sweet spot of antidystonic effect in pallidal neurostimulation
Objective: We investigated Volumes of Neural Activation (VNAs) in dystonia subjects under effective bilateral pallidum deep brain stimulation (DBS). We aimed to disentangle the sweet…Fahr’s syndrome in a Filipino female with hearing loss and polycystic ovaries: A case report
Objective: The objective of this case report is to document a case of Fahr's syndrome including its varied clinical manifestations. Background: Idiopathic basal ganglia calcification,…
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