Alpha-synuclein DNA methylation in CD45+ blood cells in Parkinson’s disease
Objective: We examined the methylation status of the DNA SNCA-intron1 at CD45+ blood cells in patients with sporadic Parkinson's disease (PD). Background: PD is a…Long term safety of levodopa/carbidopa infusion with ND0612: Results from a phase 2b, international, open-label study
Objective: The primary objective of this long-term study was to evaluate the safety and tolerability of a 24-hour regimen and a 16-hour ‘waking day’ regimen…Opicapone and entacapone as add-on therapy to the treatment of infusions of levodopa-carbidopa intestinal gel in patients with advanced Parkinson’s disease
Objective: To study the effect of COMT inhibitors (opicapone and entacapone) in Parkinson's disease (PD) patients on levodopa-carbidopa intestinal gel (LCIG) and an insufficient control of…Motor- and Non-motor Symptoms in Patients Treated with 24-hour Daily Levodopa-Carbidopa Intestinal Gel Infusion: Analysis of the COSMOS Observational Study
Objective: Describe and compare demographic and clinical characteristics, motor, and non-motor symptoms for patients with advanced Parkinson’s disease (APD) by daily duration (<24 hours or…Altered interhemispheric synchrony in Parkinson’s disease patients with levodopa-induced dyskinesias
Objective: Our investigation aimed to explore interhemispheric functional alterations and its corresponding morphological synchronization changes. Background: Levodopa-induced dyskinesias are common motor complication of Parkinson’s disease…Rapid on-time onset and sustained improvements in motor states throughout the day following treatment with levodopa/carbidopa intestinal gel (LCIG) vs immediate-release levodopa/carbidopa oral capsules (LCIR)
Objective: To assess the speed of on-time onset and characterize the patterns of motor states throughout the day in advanced Parkinson’s disease patients treated with…Gut Microbiote Distinctive Features and Microbiota-Metabolome Profile in Parkinson’s Disease: Focus on Levodopa and LCIG
Objective: The aim of this work was to study the microbiome of PD patients, studying the effect of dopaminergic drugs mainly focusing on the effect…Levodopa Challenge Test for Prediction of Deep Brain Stimulation Efficacy on Motor Functions for Parkinson’s Disease
Objective: To investigate the correlation between pre-operative response to levodopa following levodopa challenge test and the efficacy of deep brain stimulation (DBS) on motor functions…Levodopa improves tremor symptom by reducing the connectivity between the thalamic subregions and postcentral gyrus in patients with Parkinson’s disease
Objective: To explore the mechanism by which levodopa modulates the functional connectivity of the subregions of the thalamus and which subregional connectivity changes are associated…Researches on the correlation between wearable device data and UPDRS scores in patients with Parkinson’s disease
Objective: To collect spatiotemporal parameter information of motor symptoms in patients with Parkinson's disease (PD) using wearable device, and analyze its correlation with the Unified…
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