Clinical and Neuroimaging Findings in ANO10-Related Cerebellar Ataxia: Evidence of Widespread Brain Atrophy
Objective: The aim of this study was to evaluate clinical manifestations and magnetic resonance imaging (MRI) changes in patients with ANO10 gene mutations. Background: Neurodegenerative…Increased Basal Ganglia And Default-Mode Network Connectivity And Altered Deep Gray Matter Volume In Functional Movement Disorders
Objective: This study aims to investigate alterations in brain functional connectivity (FC) and deep gray matter volume in patients with Functional Movement Disorders (FMD) compared…Decreased DTI-ALPS Indices and their Association with Clinical Features in Parkinson’s Disease
Objective: To investigate possible glymphatic dysfunction using diffusion tensor image along the perivascular space (DTI-ALPS) in patients with Parkinson’s disease and their relationship with clinical…Turning Points in Disease Progression: Detecting MRI Biomarker Transitions in SCA3 Using Longitudinal Data
Objective: This study aims to identify data-driven turning points in MRI biomarkers of SCA3 to characterize region-specific disease transitions and inform early intervention strategies. Background: SCA3…Impact 360 Study for Parkinson’s Disease – a controlled phase II feasibility and safety study of a combined exercise, diet and mindfulness intervention
Objective: The aim of this phase II controlled trial is to evaluate the safety, feasibility, and to explore the effects of a multimodal intervention in…Longitudinal MRI Study of Hippocampal Subfields Morphometry in Early Parkinson’s Disease
Objective: This prospective cohort study longitudinally investigated hippocampal subfield shape deformation and atrophy in early-stage Parkinson’s Disease (PD), using spherical harmonic-based shape analysis. Background: Hippocampal…Machine Learning Analysis of DTI-Derived Free Water Reveals Distinct Parkinson’s Disease Subtypes: A Two-Year Longitudinal Study
Objective: To identify distinct subtypes of Parkinson’s disease (PD) based on diffusion tensor imaging (DTI)-derived free water (FW) patterns in basal ganglia (BG) structures using…Brain Structural Impairment in Spinocerebellar Ataxia Type 6: Not Restricted to the Cerebellum
Objective: To characterize the structural brain signature in SCA6 patients. Background: Spinocerebellar ataxias (SCA) refer to a group of autosomal dominant ataxic disorders that result…A Randomized Clinical Trial of Immersive Virtual Reality and Cognitive Rehabilitation for Mild Cognitive Impairment in Parkinson’s Disease
Objective: To investigate the efficacy of Immersive Virtual Reality (IVR) and Computerized Cognitive Training (CCT) for mild cognitive impairment in Parkinson’s disease (PD-MCI) Background: PD-MCI…The Associations between Cognitive Reserve Proxies, Multimodal MRI Brain Measures and Cognition, Motor Function and Mood in Parkinson’s Disease
Objective: This study aimed to use multimodal MRI to explore the relative importance of cognitive reserve (CR) proxies, compared to CR- and Parkinson’s disease (PD)-related…
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