Beyond Motor Symptoms: Utilizing the FreeSurfer Brainstem Substructures Module to Characterize a Complex Parkinsonian Phenotype with Profound Dysautonomia
Objective: To describe the autonomic function profile and quantitative brainstem substructures analysis in a 62-year-old male of Parkinsonism complicated by severe autonomic failure and neuropsychiatric…Cortical Mean Diffusivity as a Measure of Microstructural Neurodegeneration in Multiple System Atrophy
Objective: To characterize cortical microstructural alterations in multiple system atrophy (MSA) and to examine their associations with clinical features and neuropsychological performance. Background: Cortical mean…Machine Learning–Based Brain Age Modeling Reveals Accelerated Structural Degeneration in Parkinson’s Disease
Objective: To compare the rate of global brain structural degeneration between healthy controls (HC) and patients with Parkinson’s disease (PD). Background: Normal aging is accompanied…Image-Guided DBS Programming in Dystonia: Experience from a Tertiary Public Brazilian Center
Objective: To illustrate the clinical utility of postoperative DBS lead reconstruction and image-guided programming in genetic dystonia Background: DBS of the globus pallidus internus (GPi)…Computer-Assisted Morphometric Analysis of Midbrain and Pons for Differential Diagnosis of Parkinsonian Disorders
Objective: To evaluate the diagnostic utility of a computer-assisted elliptical fitting tool for standardized measurement of the midbrain and pons in differentiating progressive supranuclear palsy…Distinct Neurostructural, Cognitive, and Neuropsychiatric Associations of Plasma p-tau217, and Aβ42/40 in Parkinson’s Disease and Aging Cohorts
Objective: To investigate associations between plasma biomarkers of Alzheimer’s disease (AD) pathology [phosphorylated-tau-217 (p-tau217), amyloid-beta-42/40 (Aβ42/40)], neurodegeneration [neurofilament light chain (NfL)], and neuroinflammation [glial fibrillary…Sequential neurodegenerative trajectories across the onset of mild parkinsonian signs in isolated REM sleep behavior disorder: a longitudinal multimodal imaging study
Objective: To demonstrate the neurodegeneration status implied by mild parkinsonian signs (MPS) in patients with isolated REM sleep behavior disorder (iRBD) by analyzing longitudinal clinical…Bilateral MRgFUS thalamotomy in essential tremor: a prospective case series using probabilistic tractography
Objective: To evaluate the efficacy and safety of staged bilateral MRgFUS thalamotomy guided by probabilistic tractography. Background: Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is an…Does Fgatir Hypointensity Predict Outcomes After Deep Brain Stimulation For Action Tremors
Objective: To test whether efficacy of Deep Brain Stimulation (DBS) in different action tremor syndromes (Essential tremor, ET, ET-plus, or dystonic tremor as per IPMDS…Local Glymphatic Dysfunction in Multiple System Atrophy: Insights from Multimodal MRI
Objective: To evaluate multimodal glymphatic-related MRI proxies in multiple system atrophy (MSA) and explore their relationship with clinical features. Background: Impaired fluid transport and waste…
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