Novel Structural MRI-Based Progression Subtypes and Prognostic Study in Multiple System Atrophy
Objective: To identify structural MRI-based progression subtypes in multiple system atrophy (MSA) and determine whether these imaging-defined subtypes are associated with distinct clinical features, molecular…Automated Differentiation for Early Parkinsonism Using Clinical Structural MRI: A Multicenter Study
Objective: To develop and validate a T1-weighted structural MRI–based machine learning model for differentiating Parkinsonism at early-to-mid stage and generalize the model to routine anisotropic…Cerebral Small Vessel Disease-Related Degeneration of Cholinergic Pathways Contributes to Cognitive Impairment in Parkinson’s Disease
Objective: To determine whether cerebral small vessel disease (SVD) metrics contributes to cognitive impairment in Parkinson’s disease (PD) through microstructural damage to cholinergic projection pathways.…Electrode implantation outcome evaluation based on diffusion-tensor imaging math processing for PD patients with DBS
Objective: In this paper, approach for simultaneous analysis of tract density and T1 MRI with fractional anisotropy map is proposed for implantation outcome evaluation and…Multi-tracer positron emission tomography reveals early disruption of cerebrospinal fluid clearance in Huntington’s disease
Objective: To evaluate lateral ventricular (LV) positron emission tomography (PET) signal and choroid plexus (CP) volume as biomarkers of disease progression in Huntington’s disease (HD),…12-week Aerobic Interval Training Induces Hemisphere-Specific Neuroprotection in Parkinson’s Disease: A Multimodal MRI, [18F]Fluorodopa PET/CT and BDNF Study
Objective: To investigate whether a 12-week aerobic interval training (AIT) can preserve subcortical brain structures in early Parkinson’s disease (PD) and whether these effects are…Multicenter Evaluation of Automated Structural MRI-based Diagnosis for Multiple System Atrophy
Objective: This study aims to evaluate whether automated classification based on individual voxel-based morphometry (VBM) adjusting covariates (iVAC) can achieve high diagnostic accuracy for MSA…Subtype-specific alterations of iron deposition and neuromelanin loss in the substantia nigra of Parkinson’s disease
Objective: To investigate the specific pathological changes in the substantia nigra (SN) across Parkinson’s disease (PD) subtypes, focusing on iron deposition and NM depletion both…Plasma Phospho-Tau217 and Neuromelanin-Sensitive MRI as Candidate Biomarkers in Beta-Propeller Protein-Associated Neurodegeneration
Objective: To evaluate plasma phosphorylated tau at threonine 217 (pTau217) and neuromelanin-sensitive MRI (NM-MRI) as candidate biomarkers reflecting tau pathology and nigral iron deposition in…AI guided presurgical risk stratification for deep brain stimulation surgery
Objective: To develop and validate an artificial intelligence (AI) machine learning (ML) model for preoperative cognitive risk stratification for deep brain stimulation surgery (DBS). Background:…
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