Mitochondrial Density Shapes Regional Vulnerability to Atrophy in Parkinson’s Disease
Objective: To characterise the coupling between regional mitochondrial density and complex I activity and spatially patterned brain atrophy in Parkinson's disease (PD), and its variation…Dual-Site Transcranial Magnetic Stimulation Ameliorates Freezing of Gait in Parkinson’s Disease by Remodeling Cortical Excitatory-Inhibitory Balance and White Matter Microstructure: A Randomized Controlled Trial
Objective: To investigate whether dual-site [DS, primary motor cortex (M1) + supplementary motor area (SMA)] repetitive transcranial magnetic stimulation (rTMS) could attain superior efficacy compared…White Matter Hyperintensity and the Spatial Subtypes in Parkinson’s Disease
Objective: To determine whether white matter hyperintensity (WMH) volume and its spatial subtypes, periventricular WMH (PWMH) and deep WMH (DWMH), are associated with cognitive impairment…Latent Classes of Cognitive Decline in Parkinson’s Disease: Neuroimaging and Neurodegenerative Blood Biomarker Correlates
Objective: To identify longitudinal trajectories of cognitive decline in Parkinson’s disease (PD) and to characterize neuroimaging and neurodegenerative blood biomarker correlates. Background: Cognitive impairment affects…fMRI Activity during Working Memory Manipulation is Associated with Caudate Integrity in Early Parkinson’s Disease
Objective: This study aimed to determine whether reduced dopaminergic integrity and increased iron deposition in the caudate are associated with altered BOLD activation during high…Diffusion MRI Evidence of Cerebellar Involvement in Cognitive Dysfunction in Parkinson’s Disease
Objective: To determine whether cerebellar axonal microstructural abnormality is associated with cognitive performance in PD. Background: Cognitive impairment in Parkinson’s disease (PD) often affects executive…Coupling between global BOLD signal and cerebrospinal fluid flow in isolated REM sleep behavior disorder and its relation with non-motor symptoms.
Objective: To explore changes in global BOLD (gBOLD) signal and cerebrospinal fluid flow (CSF) coupling in isolated REM sleep behavior disorder (iRBD) as a Magnetic…Structural-Functional Coupling Supporting Motor Reserve in Early-Stage Parkinson’s Disease
Objective: To explore whether motor reserve in early Parkinson's disease (PD) is related to structural-functional coupling (SFC) Background: Motor reserve contributes to individual variability in…Cross-Sectional and Longitudinal MRI Biomarkers of Neurodegeneration in Friedreich’s Ataxia
Objective: - To identify structural CNS changes associated with Friedreich’s ataxia (FRDA).- To characterize their longitudinal progression. Background: Friedreich’s ataxia (FRDA), the most common inherited…Genetic Architecture Of Intracranial Brain Calcification: A Systematic Review
Objective: To systematically identify monogenic disorders associated with intracranial intraparenchymal brain calcification and synthesise their clinical, radiological and molecular features. Background: Brain calcification is a…
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