Modeling Cerebellar Limb Dysmetria and Impaired Spatial Memory in Rats Using Lamivudine: A preliminary study
Objective: This study is aimed at determining if any constituent of combination antiretroviral therapy (cART) can induce cerebellar limb dysmetria and spatial memory impairments in…A longitudinal PET study to assess the state of microglia activation in a Phase 2 study of Laquinimod as a treatment for Huntington’s disease (LEGATO-HD)
Objective: To assess in vivo in Huntington’s disease (HD) changes in microglia activation state, due to treatment with laquinimod, as reflected by changes in 11C-PBR28…hUC-MSCs ameliorated CUMS-induced depression by modulating complement C3 signaling-mediated microglial polarization during astrocyte-microglia crosstalk
Objective: To demonstrate whether hUC-MSCs can benefit depressive-like behavior by altering C3/C3a-C3aR signaling to impact microglia polarization in the CUMS model. Background: Major depressive disorder (MDD) has been…A study of gut microbiota dynamics in Parkinsonian mice
Objective: To examine gut microbiota in the M83 mouse model of PD. Background: Parkinson’s disease (PD) is a chronic neurodegenerative disease characterized by motor and…Activity of Cerebral Networks, Amyloid and Microglia in Corticobasal Syndrome: the ActiGliA study
Objective: The purpose of this prospective cohort study is to analyse the topographical and temporal relationship between cerebral microglia activity changes, network degeneration and atrophy…A Study of Microglial Metabolism in Neuroinflammation
Objective: Targeting of microglial metabolism may be a potential therapeutic option for diseases such as PD [Parkinson’s Disease] and LBD [Lewy Body Dementia]. To establish…Differential glial and neuronal response in Lipopolysaccharide induced Parkinson’s disease model: Modulation with Apocyanin and Curcumin
Objective: To understand the differential susceptibility of neuronal and glial populations to lipopolysaccharide (LPS) mediated insult in an animal model of PD. Also, to test…Metabolomic Profiling of Activated Microglial Cells
Objective: To investigate metabolomic changes in SIM-A9 microglia in vitro following exposure to neuroinflammatory insult using high resolution mass spectrometry. Background: Microglial cells play an…Bmal1 deficiency aggravates MPTP-induced dopaminergic cell death through promoting neuroinflammation
Objective: Bmal1 is one of the most important central clock genes of circadian rhythm. Circadian rhythm dysfunction is one of the non-motor symptoms in Parkinson’s…Neuroprotection effects of probiotics strains on a chronic MPTP-induced mouse model of Parkinson’s disease
Objective: To explore the effects of probiotics strains on the neuroinflammation and degeneration of dopaminergic neurons in chronic Parkinson’s disease (PD) mice model. Background: Microglia-mediated…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.