hUC-MSCs ameliorated CUMS-induced depression by modulating complement C3 signaling-mediated microglial polarization during astrocyte-microglia crosstalk
Objective: To demonstrate whether hUC-MSCs can benefit depressive-like behavior by altering C3/C3a-C3aR signaling to impact microglia polarization in the CUMS model. Background: Major depressive disorder (MDD) has been…A study of gut microbiota dynamics in Parkinsonian mice
Objective: To examine gut microbiota in the M83 mouse model of PD. Background: Parkinson’s disease (PD) is a chronic neurodegenerative disease characterized by motor and…Andrograholide protect microglial activation via inhibiting mitochondrial ROS generation and NLRP3 inflammasome activation in in-vitro and in-vivo model of Parkinson’s disease
Objective: Parkinson's disease (PD) is a distressing neurodegenerative disorder effecting nearly 2-3% of the total population greater than 65 years old . Several mechanisms have…18kDa Translocator Protein PET in 4-Repeat Tauopathies – A Cross-Sectional Single Center Study
Objective: The aim of this single center study was to analyse the potential of 18F-GE-180 TSPO PET as a biomarker in 4R-tauopathies. Background: The pathological…Activity of Cerebral Networks, Amyloid and Microglia in Corticobasal Syndrome: the ActiGliA study
Objective: The purpose of this prospective cohort study is to analyse the topographical and temporal relationship between cerebral microglia activity changes, network degeneration and atrophy…A Study of Microglial Metabolism in Neuroinflammation
Objective: Targeting of microglial metabolism may be a potential therapeutic option for diseases such as PD [Parkinson’s Disease] and LBD [Lewy Body Dementia]. To establish…Differential glial and neuronal response in Lipopolysaccharide induced Parkinson’s disease model: Modulation with Apocyanin and Curcumin
Objective: To understand the differential susceptibility of neuronal and glial populations to lipopolysaccharide (LPS) mediated insult in an animal model of PD. Also, to test…Metabolomic Profiling of Activated Microglial Cells
Objective: To investigate metabolomic changes in SIM-A9 microglia in vitro following exposure to neuroinflammatory insult using high resolution mass spectrometry. Background: Microglial cells play an…Bmal1 deficiency aggravates MPTP-induced dopaminergic cell death through promoting neuroinflammation
Objective: Bmal1 is one of the most important central clock genes of circadian rhythm. Circadian rhythm dysfunction is one of the non-motor symptoms in Parkinson’s…Neuroprotection effects of probiotics strains on a chronic MPTP-induced mouse model of Parkinson’s disease
Objective: To explore the effects of probiotics strains on the neuroinflammation and degeneration of dopaminergic neurons in chronic Parkinson’s disease (PD) mice model. Background: Microglia-mediated…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.