[11C]PK11195 PET in Alzheimer’s disease and progressive supranuclear palsy: the NIMROD study
Objective: Here we test whether the intensity and regional distribution of neuro-inflammation differs between Alzheimer's disease (AD), Progressive Supranuclear Palsy (PSP) and controls; and whether neuro-inflammation…Study of neuroprotective effects of Ginsenside Rg3 , the prototypal epigenetic Sirtuin-1 activator, in targeting microglia activation and neurotrophic factor (NF) neural plasticity in MPTP model of Parkinson’s disease (PD)
Objective: 1) to examine whether the phyto-neurosteroid: Ginsenoside Rg3 recently demonstrated to activate the epigenetic SIRTI signaling, will rescue the motor impairment in rodent model…Interactions between amyloid-β and microglial activation in Parkinson’s disease
Objective: To evaluate the relationship between microglial activation and amyloid-β deposition in the brain using positron emission tomography (PET) in Parkinson’s disease (PD) with normal…The role of neuroinflammation in the development of Parkinson’s disease dementia
Objective: To evaluate, at post-mortem, the pattern and characteristics of neuroinflammatory change in Parkinson's disease (PD) brain and to assess its relationship with aberrant alpha-synuclein,…Glial cells and iron accumulation in the brain of the Zitter rat
Objective: To investigate relationship between glial cell and iron accumulation in the brain of the Zitter rat, which is one of neurodegenerative disease model. Background:…Curcumin supplementation improves motor dysfunction in lipopolysaccharide induced Parkinon’s disease model: Possible biochemical, neurochemical and immunohistochemical alterations in rats
Objective: In the present study potential neuroprotective effects of curcumin were tested to determine if they could help to minimize microglia–mediated damage in single intranigral…Leukocyte perturbations suggest immune dysregulation in progressive supranuclear palsy
Objective: Compare the serum cytokine profiles and phenotypes of peripheral blood mononuclear cells (PBMCs) in a patient with Progressive Supranuclear Palsy (PSP) with his healthy…Glatiramir acetate (Copaxone) causes restoration of the striatal dopamine in a progressive MPTP mouse model of Parkinson’s disease
Objective: To assess if a microglial modulator, Glatiramer Acetate (GA), can restore loss of striatal dopamine (DA) and behavioral deficits following progressive 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)…Effect of intra-striatal 6-OHDA lesion on extra-striatal structures in the mouse
Objective: Characterization of extra-striatal manifestations in the 6-hydroxydopamine (6-OHDA) Parkinson's disease (PD) animal model. Background: PD is a neurodegenerative disorder characterized by progressive loss of…Modulation of microglia function in the prion-like spreading of α-synuclein in the murine brain
Objective: We aimed to analyze the influence of two microglia-related pathways on the accumulation of α-synuclein aggregates and neurodegeneration after intracerebral injection of sonicated murine…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.