Cerebellar-cortical-spinal information flow for motor kinematic control
Objective: If M1 generates final motor outputs and cerebellar temporal kinematic information must pass through M1, then M1 should relay cerebellar frequency codes to the…External Validation of a Machine Learning Classifier for Motor Progression in Parkinson’s Disease
Objective: To externally validate a previously published machine learning (ML) classifier for predicting motor symptom progression in Parkinson’s disease (PD) using an independent clinical dataset.…Dysphagia and Oropharyngeal Freezing in Progressive Supranuclear Palsy
Objective: To investigate the characteristics and mechanism of dysphagia in patients with Progressive Supranuclear Palsy(PSP). Background: Up to 79% of patients with PSP suffer from…Cortical Oscillatory Dynamics during Turning in Parkinson’s Disease using OPM-MEG
Objective: To non-invasively characterise cortical oscillatory activity in Parkinson’s disease (PD), with high spatial resolution, during a turning task, and to compare sensorimotor dynamics between…Effects of Chronic IEM-1460 Treatment on Perineuronal Net–Parvalbumin Interneuron Association in L-DOPA-Induced Dyskinesia
Objective: To determine whether chronic IEM-1460 administration alters dyskinesia and perineuronal net (PNN)–parvalbumin interneuron (PV-IN) association in a 6-OHDA rat model of L-DOPA-induced dyskinesia (LID).…Differential Motor Cortex Compensation in Parkinson’s Disease based on Putamen Neurodegeneration Laterality: Insights from EEG and [¹⁸F]FDOPA PET/CT
Objective: To investigate differences in motor cortex compensation across Parkinson’s disease (PD) patients with different putamen neurodegeneration laterality. Background: Abnormalities in the putamen–motor cortex (M1)…Decrease in Walking Ability with Increased Functional Connectivity between Multiple Brain Areas in Parkinson’s Disease
Objective: To compare the functional connectivity of PFC, PMC, and PSC regions during walking between individuals with Parkinson's disease and healthy controls. Background: Gait disturbances…Reduced parietal and sensorimotor cortex recruitment during complex gait in Parkinson’s disease patients with freezing of gait
Objective: To investigate cortical brain activity changes during complex gait in Parkinson’s disease (PD) patients with and without freezing of gait (FOG) using functional near…Complexity of fractal patterns in motor cortical oscillatory activity in rodent models of Parkinson disease
Objective: To investigate whether motor cortical oscillation changes in fractal patterns are associated with a change in the FD in the HALO and the 6-OHDA…Oscillatory network mapping of deep brain stimulation outcomes in Parkinson’s disease
Objective: Use combined local field potential (LFP) and Magnetoencephalography (MEG) recordings to map whole-cortex oscillatory connectivity and estimate deep brain stimulation (DBS) outcome. Background: Subthalamic…
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