A prospective single-center study investigating the utility of supportive features in the diagnosis of multiple system atrophy with predominant cerebellar ataxia
Objective: The present study aimed to determine the utility of supportive motor and nonmotor features in differentiating multiple system atrophy (MSA) with predomainat cerebellar ataxia…Validation of the Chinese Version of the Unified Multiple System Atrophy Rating Scale
Objective: To assess the psychometric properties of the Chinese version of the Unified Multiple System Atrophy Rating Scale (UMSARS). Background: The UMSARS is the gold‑standard…Divergent Glymphatic Dysfunction and Free Water Pathology Underpin Distinct Mechanisms and Enable Differential Diagnosis in Parkinson’s Disease and Multiple System Atrophy
Objective: To evaluate glymphatic function and FW pathology in PD and MSA, and to develop an integrated biomarker panel for differential diagnosis. Background: Parkinson's disease…Pattern and progression of sudomotor dysfunction in alpha synucleinopathies
Objective: This study examined the distribution and longitudinal progression of sweat loss in patients with PAF. Background: Pure autonomic failure (PAF) is an alpha-synucleinopathy with…Automated Speech Analysis for the Differentiation of Multiple System Atrophy from Parkinson’s Disease in an English-Speaking Cohort
Objective: The aim of this pilot study was to determine whether automatically extracted speech features, derived from targeted speech tasks, can differentiate Multiple System Atrophy…Automated Differentiation for Early Parkinsonism Using Clinical Structural MRI: A Multicenter Study
Objective: To develop and validate a T1-weighted structural MRI–based machine learning model for differentiating Parkinsonism at early-to-mid stage and generalize the model to routine anisotropic…Beyond Diagnosis: Putaminal ADC Hyperintensity and Infratentorial Signs Reflect Motor Severity in MSA
Objective: To clarify the clinical significance of neuroimaging markers in multiple system atrophy (MSA) by (1) examining concordance among putaminal MRI markers across sequences, (2)…Does CANVAS mimic MSA-C
Objective: To describe the natural history of RFC1-related ataxia, identify discriminative features compared to MSA-C, and study their survival outcomes. Background: AAGGG intronic expansions in…Proteome-Wide Association and Mendelian Randomization Analyses Identify Plasma GUSB as a Potential Biomarker for Multiple System Atrophy
Objective: To identify plasma protein biomarkers associated with MSA and investigate their potential causal relationships using integrative proteomic and genetic approaches. Background: Multiple System Atrophy…Evaluation of Semantic Space Search Metrics in Phonemic Fluency: Comparison among Basal Ganglia Disorders and Healthy Controls
Objective: Phonemic verbal fluency reflects executive function and involves both within-category lexical retrieval (cluster size) and switching between categories. We compared semantic search behavior in…
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