Low Level of Serum Total Cholesterol Predicts Mortality in Early-stage Multiple System Atrophy: a Prospective-cohort Study
Objective: The study aims to clarify the association between baseline level of serum TC and survival of patients with early MSA. Background: Serum total cholesterol…Balance biomarker for early differentiation of Parkinson’s disease and multiple system atrophy with parkinsonian type
Objective: We propose a random forest model utilizing balance analysis to differentiate early-stage Parkinson’s disease (PD) and multiple system atrophy with parkinsonian type (MSA-P) patients.…Anal Sphincter EMG changes can Progress over Time and can be considered as a Prognostic Marker in MSA
Objective: To assess the usefulness of repeat anal sphincter EMG for prognostication of MSA Background: External anal sphincter (EAS) electromyography (EMG) is an established method…Blood and CSF Biomarkers of Cognitive Impairment in Alpha Synucleinopathies
Objective: The aim was to investigate the role of both well-established and novel protein biomarkers of cognitive impairment in Parkinson’s disease (PD) and multiple system…Altered Tryptophan Metabolism and the Role of the Kynurenine Pathway in Multiple System Atrophy
Objective: To elucidate cerebrospinal fluid (CSF) tryptophan metabolism in multiple system atrophy (MSA), focusing on alterations in the kynurenine pathway and its pathological implications. Background:…Real world application of alpha-synuclein skin biopsy in the diagnosis of synucleinopathies at a tertiary care center
Objective: The goal of this study is to review the real-world application of alpha-synuclein skin biopsy at a tertiary care center. Background: Synucleniopathies including Parkinson’s…Is Urinary Retention a Marker of Possible Prodromal MSA in PAF?
Objective: This study aims to evaluate the role of post-void urinary residual volume (PVR) in Pure Autonomic Failure (PAF) and its prognostic value as a…Proteomic analysis identifies GGA1, SCP2, and RABEPK as risk protein of multiple system atrophy
Objective: Investigating proteomic changes preceding MSA onset to provide critical insights into disease biology, uncover novel biomarkers for early detection, and identify potential therapeutic targets.…Cutaneous Phosphorylated Alpha-Synuclein Deposition in Multiple System Atrophy
Objective: To report differences in the amount, localization and topographic distribution of cutaneous P-SYN deposition between cerebellar and parkinsonian variants of MSA. Background: MSA is…Predictive clinical factors for the faster progression from idiopathic late-onset cerebellar ataxia to multiple system atrophy cerebellar type
Objective: Our study aims to investigate the clinical parameters associated with faster conversion from late-onset cerebellar ataxia (ILOCA) to multiple system atrophy cerebellar type (MSA-C)…
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