Discharge rate dependency of bursting of pallidal neurons underlying choreic movements
Objective: To investigate the physiological mechanisms of neurons in the basal ganglia motor circuit underlying choreic movements. Background: Synchronized burst discharges and the low discharge…Differences in subthalamic oscillatory neuronal activity associated with severity in Parkinson’s disease
Objective: To investigate whether altered neuronal activity in the subthalamic nucleus (STN) is associated with severity in patients with Parkinson’s disease (PD). Background: PD is…Exploring the pathophysiology of acquired dystonia by the use of high frequency somatosensory stimulation
Objective: To explore the effect of high-frequency repetitive sensory stimulation (HF-RSS) on the excitability of the sensorimotor cortex in acquired dystonia Background: Dystonia is currently…Visual Hallucinations and Illusions in Parkinson’s Disease: The Role of Ocular Pathology
Objective: To determine whether different mechanisms could lead to the emergence of visual hallucinations (VH) (defined as false perceptions with no external stimulus) versus illusions…Gait and motion analysis in Progressive Supranuclear Palsy
Objective: Evaluate gait abnormalities in progressive supranuclear palsy (PSP) with three-dimensional motion analysis. Background: PSP is associated with complex, disabling gait and balance abnormalities that…Pain Syndromes in Parkinsonism Depending on the Form Disease
Objective: To study of pain syndromes in various forms of Parkinsonism. Background: Pain can occur in the premotor stage of Parkinson's disease, motor signs are…Characterization of pallidal neuronal activity in X-linked dystonia-parkinsonism – a model disease for compartment degeneration in the striatum
Objective: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is a highly effective symptomatic therapy for dystonia in X-linked dystonia-parkinsonism (XDP). A deeper…An agent-based model replicates the pathogenic spread of alpha-synuclein in mice
Objective: To investigate the ability of a susceptible-infected-removed (SIR) agent-based model to predict the pathogenic spread of alpha-synuclein fibrils after injection in mice. Background: Parkinson’s…Detection of impaired finger dexterity by objective keyboard typing test in Parkinson’s Disease: A feasibility study
Objective: To objectively evaluate finger dexterity in Parkinson’s disease (PD) patients by keyboard typing test. Background: Impaired motor dexterity is a type of bradykinesia which…Does lesion localisation predict tremor characteristics in patients with focal cerebellar lesion?
Objective: To determine if lesion localisation correlates with tremor characteristics in patients with focal cerebellar lesion. Background: It is a clinical experience that acute lesions…
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