Neuropsychiatric Symptom Evolution Over the First Decade of Biomarker-Defined Parkinson’s Disease
Objective: To examine the evolution of neuropsychiatric symptoms (NPS) in biomarker-defined Parkinson’s disease over the first decade following diagnosis. Background: Parkinson’s disease (PD) is frequently…Challenges of Translating the MDS-UPDRS into Ukrainian During Wartime
Objective: To describe the practical, linguistic, and logistical challenges encountered during the Ukrainian translation and cultural adaptation of the MDS-UPDRS. Background: The process of translating…Mild Parkinsonian Signs in Prodromal Parkinson’s Disease
Objective: To investigate the prevalence and severity of mild Parkinsonian motor signs in a longitudinal cohort stratified by the Movement Disorder Society (MDS) prodromal risk…Clinical instability and fluctuations as an early marker of accelerated progression
Objective: To determine whether early clinical instability, quantified through combined motor and non-motor fluctuations, predicts a more severe longitudinal disease course in Parkinson’s disease. Background:…Seeing the Full Picture: How Subjective and Objective Data Capture the Daily Impact of Fluctuations in Parkinson’s disease.
Objective: To characterize the frequency, phenomenology, subjective relevance, and daily life impact of motor and non-motor fluctuations in a multicenter cohort of Parkinson’s disease (PD)…REM Sleep Behaviour Disorder (RBD) and its relation to Non-motor Symptoms in Progressive Supranuclear Palsy(PSP).
Objective: To examine the frequency of RBD in PSP and its associations with other non-motor symptoms. Background: RBD once considered rare in PSP, is now…Neuronal aSynuclein Disease Integrated Staging System (NSD-ISS) Reveals Clinically Meaningful Functional Progression and Quality-of-Life Impact in Parkinson’s Disease
Objective: To evaluate the utility of the Neuronal aSynuclein Disease Integrated Staging System (NSD-ISS) in assessing the meaningfulness of stage progression, and associations with quality…Coupling between global BOLD signal and cerebrospinal fluid flow in isolated REM sleep behavior disorder and its relation with non-motor symptoms.
Objective: To explore changes in global BOLD (gBOLD) signal and cerebrospinal fluid flow (CSF) coupling in isolated REM sleep behavior disorder (iRBD) as a Magnetic…Anhedonia in Parkinson’s Disease: Prevalence and Clinical Correlations
Objective: To investigate the prevalence of anhedonia in patients with Parkinson’s disease (PD) and to analyze its relationship with age, motor deficit severity, depression, and…Evaluation of Sleep Parameters in Parkinson’s Disease According to Disease Duration Using Ambulatory Circadian Monitoring
Objective: To evaluate clinical characteristics and objective sleep parameters in patients with Parkinson’s disease (PD) according to disease duration (<6 years versus >6 years). Background: Sleep disturbances are…
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